Why clinical trials of vitamin E and cardiovascular diseases may be fatally flawed. Commentary on "The relationship between dose of vitamin E and suppression of oxidative stress in humans"

被引：29
作者：
Blumberg, Jeffrey B.
Frei, Balz
机构：
[1] Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA
[2] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2007年 / 43卷 / 10期
关键词：
D O I：
10.1016/j.freeradbiomed.2007.08.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1374 / 1376
页数：3
相关论文
共 15 条
[1]   Mortality in randomized trials of antioxidant supplements for primary and secondary prevention - Systematic review and meta-analysis [J].
Bjelakovic, Goran ;
Nikolova, Dimitrinka ;
Gluud, Lise Lotte ;
Simonetti, Rosa G. ;
Gluud, Christian .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (08) :842-857
[2]   Long-term vitamin E supplementation fails to reduce lipid peroxidation in people at cardiovascular risk: analysis of underlying factors [J].
Chiabrando, C ;
Avanzini, F ;
Rivalta, C ;
Colombo, F ;
Fanelli, R ;
Palumbo, G ;
Roncaglioni, MC .
CURRENT CONTROLLED TRIALS IN CARDIOVASCULAR MEDICINE, 2002, 3 (1)
[3]   A Randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women - Results from the women's antioxidant cardiovascular study [J].
Cook, Nancy R. ;
Albert, Christine M. ;
Gaziano, J. Michael ;
Zaharris, Elaine ;
MacFadyen, Jean ;
Danielson, Eleanor ;
Buring, Julie E. ;
Manson, JoAnn E. .
ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (15) :1610-1618
[4]   Lipid peroxidation cannot be used as a universal criterion of oxidative stress [J].
Dotan, Y ;
Lichtenberg, D ;
Pinchuk, I .
PROGRESS IN LIPID RESEARCH, 2004, 43 (03) :200-227
[5]  
*FOOD NUTR BOARD I, 2000, DIET REF INT VIT C V, P186
[6]   Vitamin E supplements: Good in theory, but is the theory good? [J].
Greenberg, ER .
ANNALS OF INTERNAL MEDICINE, 2005, 142 (01) :75-76
[7]   Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts [J].
Knekt, P ;
Ritz, J ;
Pereira, MA ;
O'Reilly, EJ ;
Augustsson, K ;
Fraser, GE ;
Goldbourt, U ;
Heitmann, BL ;
Hallmans, G ;
Liu, SM ;
Spiegelman, D ;
Stevens, J ;
Virtamo, J ;
Willett, WC ;
Rimm, EB ;
Ascherio, A .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2004, 80 (06) :1508-1520
[8]   Vitamin E in the primary prevention of cardiovascular disease and cancer - The Women's Health Study: A randomized controlled trial [J].
Lee, IM ;
Cook, NR ;
Gaziano, JM ;
Gordon, D ;
Ridker, PM ;
Manson, JE ;
Hennekens, CH ;
Buring, JE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (01) :56-65
[9]  
Leonard SW, 2004, AM J CLIN NUTR, V79, P86
[10]   A new recommended dietary allowance of vitamin C for healthy young women [J].
Levine, M ;
Wang, YH ;
Padayatty, SJ ;
Morrow, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) :9842-9846
12