A refined method for determining the absolute configuration of the 3-hydroxy-3-methylglutaryl group

被引：22

作者：

Hattori, Yasunao

Horikawa, Ko-hei

Makabe, Hidefumi

Hirai, Nobuhiro

Hirota, Mitsuru

Kamo, Tsunashi

机构：

[1] Shinshu Univ, Fac Agr, Dept Biosci & Biotechnol, Nagano 3994598, Japan

[2] Shinshu Univ, Interdisciplinary Grad Sch Sci & Technol, Nagano 3994598, Japan

[3] Shinshu Univ, Satellite Venture Business Lab, Nagano 3868567, Japan

[4] Shinshu Univ, Grad Sch Agr, Nagano 3994598, Japan

[5] Kyoto Univ, Int Innovat Ctr, Sakyo Ku, Kyoto 6068501, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 10期

关键词：

D O I：

10.1016/j.tetasy.2007.05.013

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A refined method for the determination of the absolute configuration of the 3-hydroxy-3-methylglutaryl group in natural products was developed. An interchange between the order of reduction with lithium borohydride and amidation with a chiral amine described in the previous procedure resulted in a high yield of the desired derivative. The refined method is applicable to various natural products with the 3-hydroxy-3-methylglutaryl group, even if their available amounts are 0.1 mg. The absolute configuration of the group in the lanostane-type triterpene acid, which had been isolated in a small amount, was established as S. (C) 2007 Elsevier Ltd. All rights reserved.

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页码：1183 / 1186

页数：4

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