The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

被引：29

作者：

Berretta, Massimiliano ^{[1
]}

Quagliariello, Vincenzo ^{[2
]}

Bignucolo, Alessia ^{[3
]}

Facchini, Sergio ^{[4
]}

Maurea, Nicola ^{[2
]}

Di Francia, Raffaele ^{[5
,6
]}

Fiorica, Francesco ^{[7
]}

Sharifi, Saman ^{[8
]}

Bressan, Silvia ^{[8
,9
]}

Richter, Sara N. ^{[10
]}

Camozzi, Valentina ^{[11
]}

Rinaldi, Luca ^{[12
]}

Scaroni, Carla ^{[10
]}

Montopoli, Monica ^{[8
]}

机构：

[1] Univ Messina, Dept Clin & Expt Med, I-98100 Messina, Italy

[2] Ist Nazl Tumori IRCCS Fdn G Pascale, Div Cardiol, I-80121 Naples, Italy

[3] Ctr Riferimento Oncol Aviano CRO IRCCS, Expt & Clin Pharmacol, Via Franco Gallini 2, I-33081 Aviano, Italy

[4] Santa Maria Grazie Hosp, Oncol Operat Unit, I-80078 Naples, Italy

[5] GORI Onlus, Grp Oncol Ricercatori Italiani, I-33170 Pordenone, Italy

[6] Italian Assoc Pharmacogen & Mol Diagnost IAPharma, I-60126 Ancona, Italy

[7] AULSS 9 Scaligera, Dept Radiat Oncol & Nucl Med, I-37100 Verona, Italy

[8] Univ Padua, Dept Pharmaceut & Pharmacol Sci, I-35122 Padua, Italy

[9] Veneto Inst Mol Med, I-35129 Padua, Italy

[10] Univ Padua, Dept Mol Med, Via A Gabelli 63, I-35121 Padua, Italy

[11] Univ Padua, Dept Med DIMED, Endocrinol Unit, I-35100 Padua, Italy

[12] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Internal Med COVID Ctr, I-81100 Naples, Italy

来源：

ANTIOXIDANTS | 2022年 / 11卷 / 06期

关键词：

vitamin D; calcium homeostasis; cancer; immune system; infectious disease; 25-HYDROXYVITAMIN D STATUS; GENOME-WIDE ASSOCIATION; D-RECEPTOR POLYMORPHISMS; BONE-MINERAL DENSITY; PHASE-II TRIAL; D SUPPLEMENTATION; D DEFICIENCY; COLORECTAL-CANCER; PROSTATE-CANCER; SKELETAL-MUSCLE;

D O I：

10.3390/antiox11061090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent. Methods: A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health. Results: In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases. Conclusions: Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.

引用

页数：30

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