Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

被引：114

作者：

Saunders, Kevin O. ^{[1
,2
,3
,4
]}

Wiehe, Kevin ^{[1
,5
]}

Tian, Ming ^{[6
]}

Acharya, Priyamvada ^{[1
,2
]}

Bradley, Todd ^{[1
,5
]}

Alam, S. Munir ^{[1
,5
]}

Go, Eden P. ^{[7
]}

Scearce, Richard ^{[1
,5
]}

Sutherland, Laura ^{[1
,5
]}

Henderson, Rory ^{[1
,5
]}

Hsu, Allen L. ^{[8
]}

Borgnia, Mario J. ^{[8
]}

Chen, Haiyan ^{[1
,5
]}

Lu, Xiaozhi ^{[1
,5
]}

Wu, Nelson R. ^{[1
,5
]}

Watts, Brian ^{[1
,5
]}

Jiang, Chuancang ^{[1
,5
]}

Easterhoff, David ^{[1
,5
]}

Cheng, Hwei-Ling ^{[6
]}

McGovern, Kelly ^{[6
]}

Waddicor, Peyton ^{[6
]}

Chapdelaine-Williams, Aimee ^{[6
]}

Eaton, Amanda ^{[1
,5
]}

Zhang, Jinsong ^{[1
,5
]}

Rountree, Wes ^{[1
,5
]}

Verkoczy, Laurent ^{[1
,5
]}

Tomai, Mark ^{[9
]}

Lewis, Mark G. ^{[10
]}

Desaire, Heather R. ^{[7
]}

Edwards, Robert J. ^{[1
,5
]}

Cain, Derek W. ^{[1
,5
]}

Bonsignori, Mattia ^{[1
,5
]}

Montefiori, David ^{[1
,2
]}

Alt, Frederick W. ^{[6
]}

Haynes, Barton F. ^{[1
,4
,5
]}

机构：

[1] Duke Univ, Sch Med, Human Vaccine Inst, Durham, NC 27710 USA

[2] Duke Univ, Sch Med, Dept Surg, Durham, NC 27710 USA

[3] Duke Univ, Sch Med, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[4] Duke Univ, Sch Med, Dept Immunol, Durham, NC 27710 USA

[5] Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA

[6] Harvard Med Sch, Dept Genet, Boston Childrens Hosp, Howard Hughes Med Inst,Program Cellular & Mol Med, Boston, MA 02115 USA

[7] Univ Kansas, Dept Chem, Lawrence, KS 66049 USA

[8] NIEHS, Genome Integr & Struct Biol Lab, NIH, Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA

[9] 3M Co, Corp Res Mat Lab, St Paul, MN 55144 USA

[10] Bioqual, Rockville, MD 20850 USA

来源：

SCIENCE | 2019年 / 366卷 / 6470期

关键词：

SITE-SPECIFIC ANALYSIS; HEAVY-CHAIN GENE; NEUTRALIZING ANTIBODIES; SEQUENTIAL IMMUNIZATION; ENVELOPE TRIMERS; HIGHLY POTENT; VACCINE; GLYCOSYLATION; BROAD; IMMUNOGENICITY;

D O I：

10.1126/science.aay7199

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：1215 / +

页数：64

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