(Non-targeted) radioactive/fluorescent nanoparticles and their potential in combined pre- and intraoperative imaging during sentinel lymph node resection

被引:39
作者
Buckle, Tessa [1 ]
Chin, Patrick T. K. [1 ]
van Leeuwen, Fijs W. B. [1 ]
机构
[1] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Radiol & Nucl Med, Div Diagnost Oncol, NL-1066 CX Amsterdam, Netherlands
关键词
MODALITY MAGNETIC-RESONANCE; ISOSULFAN BLUE-DYE; QUANTUM DOTS; BREAST-CANCER; BIOPSY; PROBE; BIODISTRIBUTION; MACROMOLECULE; LOCALIZATION; MICELLES;
D O I
10.1088/0957-4484/21/48/482001
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
One clinical precedent for the use of nanosized imaging agents is the localization of the tumor draining sentinel lymph nodes. In this application, radiocolloids such as Tc-99m-NanoColl are currently used to plan the surgical procedure and to provide acoustic guidance during the intervention. Additional injections of dyes are common to provide optical surgical guidance. Bimodal imaging agents, which are both radioactive and fluorescent, have the potential to be used for both surgical planning and intraoperative fluorescence guidance towards the sentinel lymph nodes. This review provides an overview of the radioactive, fluorescent, and size properties of (non-targeted) bimodal nanoparticles, and their (potential) value in sentinel lymph node detection.
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页数:9
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