The Imperative of Responsible Innovation in Reproductive Medicine

被引：45

作者：

Mastenbroek, Sebastiaan ^{[1
]}

de Wert, Guido ^{[2
]}

Adashi, Eli Y. ^{[3
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, Amsterdam Re Prod & Dev Res Inst, Ctr Reprod Med, Amsterdam, Netherlands

[2] Maastricht Univ, Dept Hlth Eth & Soc, Res Sch GROW, Maastricht, Netherlands

[3] Brown Univ, Dept Med Sci, Providence, RI 02912 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2021年 / 385卷 / 22期

关键词：

IN-VITRO FERTILIZATION; ADVANCED MATERNAL AGE; PREIMPLANTATION GENETIC DIAGNOSIS; HUMAN EMBRYOS; CHROMOSOMAL MOSAICISM; BLASTOCYST TRANSFER; SITU HYBRIDIZATION; IMPLANTATION; ANEUPLOIDIES; PREGNANCIES;

D O I：

10.1056/NEJMsb2101718

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The introduction of in vitro fertilization (IVF) into the routine practice of reproductive medicine opened the gateway for exciting new innovations. Moreover, the accessibility of human embryos before uterine transfer made it possible to secure biopsy material for genetic analysis. In 1990, it was first reported that a procedure currently known as preimplantation genetic diagnosis was used in the genetic selection of diseasefree embryos.1 The goal of this procedure is to assist couples who are at known risk for transmitting a genetic disease in conceiving an unaffected child. However, as is often the case with the introduction of a new technology, preimplantation genetic diagnosis was soon deployed for indications other than those for which it had originally been intended. In this case, the added indication was to increase the IVF success rate (pregnancy per embryo transfer) by determining the ploidy status of the embryo. Copyright © 2021 Massachusetts Medical Society.

引用

页码：2096 / 2100

页数：5

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