Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes

被引：76

作者：

Blanchin, Stephanie ^{[1
]}

Coffin, Christine ^{[2
]}

Viader, Fausto ^{[3
]}

Ruf, Jean ^{[4
]}

Carayon, Pierre ^{[4
]}

Potier, Francette ^{[1
]}

Portier, Estelle ^{[1
]}

Comby, Elisabeth ^{[1
]}

Allouche, Stephane ^{[5
]}

Ollivier, Yann ^{[6
]}

Reznik, Yves ^{[2
]}

Ballet, Jean Jacques ^{[1
]}

机构：

[1] CHU Ciemenceau, UPRES EA 2128, Lab Immunol & Immunopathol, F-14033 Caen, France

[2] CHU Cote nacre, Serv Endocrinol & Malad Metabol, F-14033 Caen, France

[3] CHU Cote Nacre, Serv Neurol, F-14033 Caen, France

[4] Univ Aix Marseille 2, Fac Med Timone, INSERM, U555, F-13385 Marseille, France

[5] CHU Cote Nacre, Biochim Lab, F-14033 Caen, France

[6] CHU Cote Nacre, Med Interna Serv, F-14033 Caen, France

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 192卷 / 1-2期

关键词：

anti-thyroperoxidase antibodies; astrocytes; cerebrospinal fluid; Hashimoto's encephalopathy; Hashimoto's thyroiditis;

D O I：

10.1016/j.jneuroim.2007.08.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A cohort of 10 Hashimoto's encephalopathy (HE) patients, 33 patients with unrelated neurological symptoms, 12 Hashimoto's thyroiditis patients and 4 healthy adult donors was studied to explore the neurological targets of anti-thyroperoxidase (TPO) autoantibodies (aAb) in HE. High levels of anti-TPO aAb were only detected in HE group's cerebrospinal fluids. In immuno fluorescence assays on monkey brain cerebellum sections, both HE patients' sera and anti-TPO monoclonal antibodies (mAb) were able to bind cerebellar cells expressing glial fibrillary acid protein. Normal human astrocytes from primary cultures also reacted with anti-TPO mAb. Specific astrocyte binding of anti-TPO aAb suggests a role of these aAb in the HE pathogenesis. (c) 2007 Elsevier B.V All rights reserved.

引用

页码：13 / 20

页数：8

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