Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes

被引：75

作者：

Blanchin, Stephanie ^{[1
]}

Coffin, Christine ^{[2
]}

Viader, Fausto ^{[3
]}

Ruf, Jean ^{[4
]}

Carayon, Pierre ^{[4
]}

Potier, Francette ^{[1
]}

Portier, Estelle ^{[1
]}

Comby, Elisabeth ^{[1
]}

Allouche, Stephane ^{[5
]}

Ollivier, Yann ^{[6
]}

Reznik, Yves ^{[2
]}

Ballet, Jean Jacques ^{[1
]}

机构：

[1] CHU Ciemenceau, UPRES EA 2128, Lab Immunol & Immunopathol, F-14033 Caen, France

[2] CHU Cote nacre, Serv Endocrinol & Malad Metabol, F-14033 Caen, France

[3] CHU Cote Nacre, Serv Neurol, F-14033 Caen, France

[4] Univ Aix Marseille 2, Fac Med Timone, INSERM, U555, F-13385 Marseille, France

[5] CHU Cote Nacre, Biochim Lab, F-14033 Caen, France

[6] CHU Cote Nacre, Med Interna Serv, F-14033 Caen, France

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 192卷 / 1-2期

关键词：

anti-thyroperoxidase antibodies; astrocytes; cerebrospinal fluid; Hashimoto's encephalopathy; Hashimoto's thyroiditis;

D O I：

10.1016/j.jneuroim.2007.08.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A cohort of 10 Hashimoto's encephalopathy (HE) patients, 33 patients with unrelated neurological symptoms, 12 Hashimoto's thyroiditis patients and 4 healthy adult donors was studied to explore the neurological targets of anti-thyroperoxidase (TPO) autoantibodies (aAb) in HE. High levels of anti-TPO aAb were only detected in HE group's cerebrospinal fluids. In immuno fluorescence assays on monkey brain cerebellum sections, both HE patients' sera and anti-TPO monoclonal antibodies (mAb) were able to bind cerebellar cells expressing glial fibrillary acid protein. Normal human astrocytes from primary cultures also reacted with anti-TPO mAb. Specific astrocyte binding of anti-TPO aAb suggests a role of these aAb in the HE pathogenesis. (c) 2007 Elsevier B.V All rights reserved.

引用

页码：13 / 20

页数：8

共 33 条

[1] How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes [J].

Blasko, I ;

Stampfer-Kountchev, M ;

Robatscher, P ;

Veerhuis, R ;

Eikelenboom, P ;

Grubeck-Loebenstein, B .

AGING CELL, 2004, 3 (04) :169-176

[2]

BRAIN L, 1966, LANCET, V2, P512

[3] Steroid-responsive encephalopathy associated with autoimmune thyroiditis [J].

Castillo, P ;

Woodruff, B ;

Caselli, R ;

Vernino, S ;

Lucchinetti, C ;

Swanson, J ;

Noseworthy, J ;

Aksamit, A ;

Carter, J ;

Sirven, J ;

Hunder, G ;

Fatourechi, V ;

Mokri, B ;

Drubach, D ;

Pittock, S ;

Lennon, V ;

Boeve, B .

ARCHIVES OF NEUROLOGY, 2006, 63 (02) :197-202

[4] The clinical spectrum, diagnosis, pathogenesis and treatment of Hashimoto's encephalopathy (recurrent acute disseminated encephalomyelitis) [J].

Chaudhuri, A ;

Behan, PO .

CURRENT MEDICINAL CHEMISTRY, 2003, 10 (19) :1945-1953

[5] THE IMMUNODOMINANT REGION ON HUMAN THYROID PEROXIDASE RECOGNIZED BY AUTOANTIBODIES DOES NOT CONTAIN THE MONOCLONAL-ANTIBODY 47/C21 LINEAR EPITOPE [J].

CHAZENBALK, GD ;

COSTANTE, G ;

PORTOLANO, S ;

MCLACHLAN, SM ;

RAPOPORT, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (06) :1715-1718

[6] Hashimoto encephalopathy - Syndrome or myth? [J].

Chong, JY ;

Rowland, LP ;

Utiger, RD .

ARCHIVES OF NEUROLOGY, 2003, 60 (02) :164-171

[7] High-resolution in vivo imaging of the neurovascular unit during spreading depression [J].

Chuquet, Julien ;

Hollender, Liad ;

Nimchinsky, Esther A. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (15) :4036-4044

[8]

Comby E, 2006, J RHEUMATOL, V33, P24

[9] The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome [J].

Dalakas, MC ;

Fujii, M ;

Li, M ;

McElroy, B .

NEUROLOGY, 2000, 55 (10) :1531-1535

[10] Hashimoto's encephalopathy: myth or reality? An endocrinologist's perspective [J].

Fatourechi, V .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 19 (01) :53-66

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