Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities

被引：31

作者：

Bringmann, Gerhard ^{[1
]}

Hertlein-Amslinger, Barbara ^{[1
]}

Kajahn, Inga ^{[1
]}

Dreyer, Michael ^{[1
]}

Brun, Reto ^{[2
,3
]}

Moll, Heidrun ^{[4
]}

Stich, August ^{[5
]}

Ioset, Karine Ndjoko ^{[6
]}

Schmitz, Werner ^{[7
]}

Luu Hoang Ngoc

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland

[3] Univ Basel, CH-4003 Basel, Switzerland

[4] Univ Wurzburg, Inst Mol Infect Biol, D-97080 Wurzburg, Germany

[5] Med Mission Inst Wurzburg, Dept Trop Med, D-97074 Wurzburg, Germany

[6] Univ Geneva, Sect Sci Pharmaceut, Lab Pharmacognosie & Phytochim, CH-1211 Geneva 4, Switzerland

[7] Univ Wurzburg, Inst Physiol Chem, D-97074 Wurzburg, Germany

来源：

PHYTOCHEMISTRY | 2011年 / 72卷 / 01期

关键词：

Ancistrocladus cochinchinensis; Ancistrocladaceae; Naphthylisoquinoline alkaloids; Chiral N; C-axes; 4 '-O-Demethylancistrocladinium A; 6,4 '-O-Didemethylancistrocladinium A; Anti-parasitic activity; ACETOGENIC ISOQUINOLINE ALKALOIDS; TRIPHYOPHYLLUM-PELTATUM; BENOMENSIS; DIONCOPELTINE; DERIVATIVES; TECTORIUS;

D O I：

10.1016/j.phytochem.2010.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first N,8'-coupled naphthylisoquinoline alkaloids with free phenolic OH groups, 4'-O-demethylancistrocladinium A and 6,4'-O-didemethylancistrocladinium A, have been isolated from the leaves and bark of the Vietnamese liana Ancistrocladus cochinchinensis, along with its known, non-phenolic parent compound, ancistrocladinium A. and four CC-coupled representatives. The structure elucidation was achieved by chemical, spectroscopic, and chiroptical methods. The mono-phenolic alkaloid showed excellent activities in particular against the pathogen causing Chagas' disease, Trypanosoma cruzi. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：89 / 93

页数：5

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