Lipocalin-2 Deficiency Reduces Hepatic and Hippocampal Triggering Receptor Expressed on Myeloid Cells-2 Expressions in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

被引:4
作者
Shin, Hyun Joo [1 ]
Jin, Zhen [2 ]
An, Hyeong Seok [1 ]
Park, Gyeongah [2 ]
Lee, Jong Youl [1 ]
Lee, So Jeong [1 ]
Jang, Hye Min [1 ]
Jeong, Eun Ae [1 ]
Kim, Kyung Eun [1 ]
Lee, Jaewoong [1 ]
Yoo, Dae Young [1 ]
Roh, Gu Seob [1 ]
机构
[1] Gyeongsang Natl Univ, Coll Med, Inst Hlth Sci, Dept Anat & Convergence Med Sci, Jinju 52727, South Korea
[2] Univ Tennessee, Coll Med, Dept Anat & Neurobiol, Hlth Sci Ctr, Memphis, TN 38163 USA
基金
新加坡国家研究基金会;
关键词
lipocalin-2; TREM2; inflammation; diabetic mouse; UP-REGULATION; COGNITIVE DEFICITS; NEUROINFLAMMATION; TREM2; IMPAIRMENT; MICROGLIA; RESPONSES; OBESITY; SENSOR;
D O I
10.3390/brainsci12070878
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Lipocalin-2 (LCN2) is an acute-phase protein that has been linked to insulin resistance, diabetes, and neuroinflammatory diseases. Triggering receptor expressed on myeloid cells-2 (TREM2) has been also implicated in microglia-mediated neuroinflammation. However, the potential role of LCN2 on TREM2 in diabetic mouse models is not fully understood. Methods: We investigated hepatic and hippocampal TREM2 expressions in high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic LCN2 knockout (KO) mice. Results: In addition to increased serum LCN2 level, diabetic wild-type (WT) mice had insulin resistance and hepatic steatosis. However, LCN2 deletion attenuated these metabolic parameters in diabetic mice. We also found that LCN2 deletion reduced hepatic inflammation and microglial activation in diabetic mice. In particular, diabetic LCN2 KO mice had a reduction in hepatic and hippocampal TREM2 expressions compared with diabetic WT mice. Furthermore, we found that many TREM2-positive Kupffer cells and microglia in diabetic WT mice were reduced through LCN2 deletion. Conclusions: These findings indicate that LCN2 may promote hepatic inflammation and microglial activation via upregulation of TREM2 in diabetic mice.
引用
收藏
页数:11
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