The antifungal polyketide ambruticin targets the HOG pathway

被引：43
作者：
Vetcher, Leandro
Menzella, Hugo G.
Kudo, Toshiaki
Motoyama, Takayuki
Katz, Leonard
机构：
[1] Leonard Katz Consulting, Oakland, CA 94611 USA
[2] Kosan Bioisci Inc, Hayward, CA 94545 USA
[3] RIKEN, Wako, Saitama 3510198, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 10期
关键词：
D O I：
10.1128/AAC.00369-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histidine kinase.
引用
收藏
页码：3734 / 3736
页数：3
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