Steroidal saponins from the bark of Dracaena draco and their cytotoxic activities

被引：48

作者：

González, AG

Hernández, JC

León, F

Padrón, JI

Estévez, F

Quintana, J

Bermejo, J

机构：

[1] CSIC, Inst Univ Bio Organ Antonio Gonzalez, Inst Prod Nat & Agrobiol, San Cristobal la Laguna 38206, Tenerife, Spain

[2] Univ Las Palmas Gran Canaria, Dept Bioquim, Fac Med, Las Palmas Gran Canaria 35016, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 06期

关键词：

D O I：

10.1021/np020517j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the stem bark of Dracaena draco, three new compounds, namely, draconins A-C (1-3), were isolated, along with 17 known compounds. The structures of the new compounds isolated were elucidated on the basis of spectroscopic data interpretation. Several of the isolated compounds showed potent cytotoxic activities measured on the human leukemia cell line HL-60 (IC50's from 2.0 to 9.7 muM at 72 h). The mechanism by which compounds 1 and 2 display their cytostatic properties is through induction of cell death by apoptosis, as evaluated by fluorescence microscopy and DNA fragmentation.

引用

页码：793 / 798

页数：6

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