Recent advances in bioinorganic chemistry of bismuth

被引：145
作者：
Li, Hongyan [1 ]
Sun, Hongzhe [1 ]
机构：
[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2012年 / 16卷 / 1-2期
关键词：
HISTIDINE-RICH PROTEIN; HELICOBACTER-PYLORI; SARS CORONAVIRUS; METAL-BINDING; HPN-LIKE; BLOOD-PLASMA; COMPLEXES; INHIBITION; CITRATE; CELLS;
D O I：
10.1016/j.cbpa.2012.01.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway of the drugs. Mining potential protein targets inside the pathogen via metallomic/metalloproteomic approach and further characterization on the interactions of bismuth drugs with these targets laid foundation in understanding the mechanism of action of bismuth drugs. Such studies would be beneficial in rational design of new potential drugs.
引用
收藏
页码：74 / 83
页数：10
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