Self-Assembly of Amphiphilic Drug-Dye Conjugates into Nanoparticles for Imaging and Chemotherapy

被引：17
|
作者：
Sun, Tingting [1 ,2 ]
Lin, Wenhai [1 ,2 ]
Zhang, Wei [1 ,2 ]
Xie, Zhigang [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
Chemistry-An Asian Journal | 2016年 / 11卷 / 22期
基金：
中国国家自然科学基金;
关键词：
chemotherapy; conjugates; imaging; nanomedicines; self-assembly; CANCER-THERAPY; PASSERINI REACTION; SUPRAMOLECULAR NANOSTRUCTURES; DELIVERY; COMBINATION; PACLITAXEL; PRODRUGS; RELEASE; NANODRUG; PLATFORMS;
D O I：
10.1002/asia.201601206
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An amphiphilic drug-dye conjugate (PTX-Pt-BDP) was designed and synthesized with a platinum compound as the hydrophilic head. The precursor of PTX-Pt-BDP was obtained under mild conditions by means of a three-component Passerini reaction. PTX-Pt-BDP could self-assemble into nanoparticles (PTX-Pt-BDP NPs) in aqueous solution via a nanoprecipitation method. The obtained nanoparticles exhibited favorable structural stability in both water and physiological environment. PTX-Pt-BDP NPs could be endocytosed by cancer cells as revealed by confocal laser scanning microscopy and exert potent cytotoxicity. This work highlights the potential of nanomedicines from amphiphilic drug-dye conjugates for cancer cell imaging and chemotherapy.
引用
收藏
页码：3174 / 3177
页数：4
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