Self-Assembly of Amphiphilic Drug-Dye Conjugates into Nanoparticles for Imaging and Chemotherapy

被引：17
|
作者：
Sun, Tingting [1 ,2 ]
Lin, Wenhai [1 ,2 ]
Zhang, Wei [1 ,2 ]
Xie, Zhigang [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
Chemistry-An Asian Journal | 2016年 / 11卷 / 22期
基金：
中国国家自然科学基金;
关键词：
chemotherapy; conjugates; imaging; nanomedicines; self-assembly; CANCER-THERAPY; PASSERINI REACTION; SUPRAMOLECULAR NANOSTRUCTURES; DELIVERY; COMBINATION; PACLITAXEL; PRODRUGS; RELEASE; NANODRUG; PLATFORMS;
D O I：
10.1002/asia.201601206
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An amphiphilic drug-dye conjugate (PTX-Pt-BDP) was designed and synthesized with a platinum compound as the hydrophilic head. The precursor of PTX-Pt-BDP was obtained under mild conditions by means of a three-component Passerini reaction. PTX-Pt-BDP could self-assemble into nanoparticles (PTX-Pt-BDP NPs) in aqueous solution via a nanoprecipitation method. The obtained nanoparticles exhibited favorable structural stability in both water and physiological environment. PTX-Pt-BDP NPs could be endocytosed by cancer cells as revealed by confocal laser scanning microscopy and exert potent cytotoxicity. This work highlights the potential of nanomedicines from amphiphilic drug-dye conjugates for cancer cell imaging and chemotherapy.
引用
收藏
页码：3174 / 3177
页数：4
相关论文
共 50 条
  • [1] Engineered Self-Assembly of Amphiphilic Cyclodextrin Conjugates for Drug Encapsulation
    Brettner, Felix E. B.
    Schreiner, Jonas
    Vogel-Kindgen, Sarah
    Windbergs, Maike
    ACS BIOMATERIALS SCIENCE & ENGINEERING, 2022, 10 (01) : 115 - 128
  • [2] Self-assembly of Amphiphilic Tripeptides into Nanoparticles for Drug Delivery
    Tu, Zhaoxu
    Xu, Xianghui
    Jian, Yeting
    Zhong, Dan
    He, Bin
    Gu, Zhongwei
    PROTEIN AND PEPTIDE LETTERS, 2014, 21 (02): : 194 - 199
  • [3] Synthesis and Self-Assembly of Amphiphilic Ferrocene-Selenopeptide Conjugates
    Maurya, Shakti K.
    Pathak, Sushil Swaroop
    Panchakarla, Leela S.
    Singh, Harkesh B.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 2022 (06)
  • [4] Self-assembly drug conjugates for anticancer treatment
    Fumagalli, Gaia
    Marucci, Cristina
    Christodoulou, Michael S.
    Stella, Barbara
    Dosio, Franco
    Passarella, Daniele
    DRUG DISCOVERY TODAY, 2016, 21 (08) : 1321 - 1329
  • [5] Self-assembly of amphiphilic peanut-shaped nanoparticles
    Whitelam, Stephen
    Bon, Stefan A. F.
    JOURNAL OF CHEMICAL PHYSICS, 2010, 132 (07):
  • [6] Amphiphilic invertible polyurethanes: Self-assembly and synthesis of nanoparticles
    Hevus, Ivan
    Kohut, Ananiy
    Voronov, Andriy
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
  • [7] Synergistic Combination Chemotherapy of Camptothecin and Floxuridine through Self-Assembly of Amphiphilic Drug-Drug Conjugate
    Hu, Minxi
    Huang, Ping
    Wang, Yao
    Su, Yue
    Zhou, Linzhu
    Zhu, Xinyuan
    Yan, Deyue
    BIOCONJUGATE CHEMISTRY, 2015, 26 (12) : 2497 - 2506
  • [8] The characters of self-assembly core/shell nanoparticles of amphiphilic hyperbranched polyethers as drug carriers
    Ajun, Wan
    Kou Yuxia
    JOURNAL OF NANOPARTICLE RESEARCH, 2008, 10 (03) : 437 - 448
  • [9] The characters of self-assembly core/shell nanoparticles of amphiphilic hyperbranched polyethers as drug carriers
    Wan Ajun
    Kou Yuxia
    Journal of Nanoparticle Research, 2008, 10 : 437 - 448
  • [10] Controllable self-assembly of an amphiphilic drug with β-cyclodextrin and α-amylase
    Li, Shangyang
    Xing, Pengyao
    Zhang, Lin
    Xin, Feifei
    Nie, Jinhui
    Wang, Hailu
    Ma, Mingfang
    Wu, Yurong
    Hao, Aiyou
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2014, 445 : 67 - 74
12345