Alzheimer's disease: diverse aspects of mitochondrial malfunctioning

被引:1
作者
Santos, Renato X. [1 ,2 ,3 ]
Correia, Sonia C. [1 ,2 ,3 ]
Wang, Xinglong [1 ]
Perry, George [1 ,4 ,5 ]
Smith, Mark A. [1 ]
Moreira, Paula I. [2 ,6 ]
Zhu, Xiongwei [1 ]
机构
[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
[2] Univ Coimbra, Ctr Neurosci & Cell Biol Coimbra, Coimbra, Portugal
[3] Univ Coimbra, Dept Life Sci, Fac Sci & Technol, Coimbra, Portugal
[4] Univ Texas San Antonio, Dept Biol, San Antonio, TX USA
[5] Univ Texas San Antonio, UTSA Neurosci Inst, San Antonio, TX USA
[6] Univ Coimbra, Inst Physiol, Fac Med, Coimbra, Portugal
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2010年 / 3卷 / 06期
关键词
Alzheimer's disease; mitochondria; mitochondrial dysfunction; mitochondrial dynamics; AMYLOID-BETA-PEPTIDE; PERMEABILITY TRANSITION PORE; AXONAL-TRANSPORT; OXIDATIVE DAMAGE; CELL-DEATH; A-BETA; NEURONAL DYSFUNCTION; SYNAPTIC PLASTICITY; BRAIN MITOCHONDRIA; REDUCED EXPRESSION;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Alzheimer's disease is a progressive neurodegenerative disorder, either assuming a sporadic, age-associated, late-onset form, or a familial form, with early onset, in a smaller fraction of the cases. Whereas in the familial cases several mutations have been identified in genes encoding proteins related with the pathogenesis of the disease, for the sporadic form several causes have been proposed and are currently under debate. Mitochondrial dysfunction has surfaced as one of the most discussed hypotheses acting as a trigger for the pathogenesis of Alzheimer's disease. Mitochondria assume central functions in the cell, including ATP production, calcium homeostasis, reactive oxygen species generation, and apoptotic signaling. Although their role as the cause of the disease may be controversial, there is no doubt that mitochondrial dysfunction, abnormal mitochondrial dynamics and degradation by mitophagy occur during the disease process, contributing to its onset and progression.
引用
收藏
页码:570 / 581
页数:12
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