The biological mechanisms of PCNA and BMP in TMJ adaptive remodeling

被引：16

作者：

Barnouti, Zoe Potres ^{[2
]}

Owtad, Payam ^{[2
]}

Shen, Gang ^{[2
]}

Petocz, Peter ^{[3
]}

Darendeliler, M. Ali ^{[1
]}

机构：

[1] Univ Sydney, Sydney Dent Hosp, Dept Orthodont, Surry Hills, NSW 2010, Australia

[2] Univ Sydney, Dept Orthodont, Surry Hills, NSW 2010, Australia

[3] Macquarie Univ, Dept Stat, Sydney, NSW 2109, Australia

来源：

ANGLE ORTHODONTIST | 2011年 / 81卷 / 01期

关键词：

Temporomandibular joint; BMP2/4; PCNA; Mandibular advancement; ANTERIOR MANDIBULAR DISPLACEMENT; CELL NUCLEAR ANTIGEN; BONE MORPHOGENETIC PROTEIN-2; LATERAL FUNCTIONAL SHIFT; MESENCHYMAL STEM-CELLS; CONDYLAR CARTILAGE; GLENOID FOSSA; PROTRUSIVE FUNCTION; HERBST APPLIANCE; MACACA-MULATTA;

D O I：

10.2319/091609-522.1

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objectives: To histologically and immunohistochemically assess the pattern of expression of bone morphogenic proteins 2 and 4 (BMP2/4) and proliferating cell nuclear antigen (PCNA) in response to bite jumping appliances in the condylar cartilage and the glenoid fossa. Materials and Methods: Fifty-five 4-week-old female Sprague-Dawley rats were randomly divided into four experimental and four control groups. Bite-jumping appliances were fitted to the experimental animals. The rats were sacrificed at 3, 14, 21, and 30 days, and the temporomandibular structures were analyzed histologically and immunohistochemically. Results: The expression of BMP2/4 in response to bite-jumping appliances was statistically significant in the condylar cartilage and the glenoid fossa. Cell proliferation was not significant. Conclusion: BMP2/4 plays an important role in bone formation in response to mandibular advancement by accelerating and enhancing the differentiation of mesenchymal cells into bone-forming cells. (Angle Orthod. 2011;81:91-99.)

引用

页码：91 / 99

页数：9

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