Association between human rhinovirus C and severity of acute asthma in children

被引：289

作者：

Bizzintino, J. ^{[1
,2
]}

Lee, W-M.

Laing, I. A. ^{[1
,2
]}

Vang, F. ^{[6
]}

Pappas, T. ^{[6
]}

Zhang, G. ^{[1
]}

Martin, A. C. ^{[1
]}

Khoo, S-K. ^{[1
]}

Cox, D. W. ^{[1
]}

Geelhoed, G. C.

McMinne, P. C. ^{[5
]}

Goldblatt, J. ^{[1
,3
,4
]}

Gern, J. E. ^{[6
]}

Le Souef, P. N. ^{[1
]}

机构：

[1] Univ Western Australia, Sch Paediat & Child Hlth, GPO Box D184, Perth, WA 6840, Australia

[2] Univ Western Australia, Ctr Child Hlth Res, Perth, WA 6840, Australia

[3] King Edward Mem Hosp, Genet Serv, Perth, WA, Australia

[4] King Edward Mem Hosp, Familial Canc Program WA, Perth, WA, Australia

[5] Univ Sydney, Sydney, NSW 2006, Australia

[6] Univ Wisconsin, Dept Pediat, Sch Med & Publ Hlth, Madison, WI USA

来源：

EUROPEAN RESPIRATORY JOURNAL | 2011年 / 37卷 / 05期

基金：

英国医学研究理事会;

关键词：

Acute asthma; children; exacerbation severity; human rhinovirus C; rhinovirus; RESPIRATORY-TRACT INFECTIONS; IDENTIFIED HUMAN RHINOVIRUS; VIRUSES; ILLNESS; EXACERBATIONS; PREVALENCE; PATHOGENS; GENOTYPE; REVEALS; COHORT;

D O I：

10.1183/09031936.00092410

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

A new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC),has recently been discovered. We hypothesised that HRVC would be present in children with acute asthma and cause more severe attacks than other viruses or HRV groups. Children with acute asthma (n=128; age 2-16 yrs) were recruited on presentation to an emergency department. Asthma exacerbation severity was assessed, and respiratory viruses and HRV strains were identified in a nasal aspirate. The majority of the children studied had moderate-to-severe asthma (85.2%) and 98.9% were admitted to hospital. HRV was detected in 87.5% and other respiratory viruses in 14.8% of children, most of whom also had HRV. HRVC was present in the majority of children with acute asthma (59.4%) and associated with more severe asthma. Children with HRVC (n=76) had higher asthma severity scores than children whose HRV infection was HRVA or HRVB only (n=34; p=0.018), and all other children (n=50; p=0.016). Of the 19 children with a non-HRV virus, 13 had HRV co-infections, seven of these being HRVC. HRVC accounts for the majority of asthma attacks in children presenting to hospital and causes more severe attacks than previously known HRV groups and other viruses.

引用

页码：1037 / 1042

页数：6

共 31 条

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