Behavioral effects of subchronic inhalation of toluene in adult rats

被引：11

作者：

Beasley, Tracey E. ^{[1
]}

Evansky, Paul A. ^{[2
]}

Gilbert, Mary E. ^{[1
]}

Bushnell, Philip J. ^{[1
]}

机构：

[1] US EPA, Natl Hlth & Environm Effects Res Lab, Toxicol Assessment Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA

[2] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 2010年 / 32卷 / 06期

关键词：

Organic solvent; Signal detection; Fear conditioning; Motor activity; Quinpirole; Raclopride; MEDIATED LOCOMOTOR-ACTIVITY; ORGANIC-SOLVENTS; COLOR-VISION; 40; PPM; AGONIST BINDING; EXPOSURE; PERSISTENT; TASK; ATTENTION; ABUSE;

D O I：

10.1016/j.ntt.2010.05.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Whereas the acute neurobehavioral effects of toluene are robust and well characterized, evidence for persistent effects of repeated exposure to this industrial solvent is less compelling. The present experiment sought to determine whether subchronic inhalation of toluene caused persistent behavioral changes in rats. Adult male Long-Evans rats inhaled toluene vapor (0, 10, 100, or 1000 ppm) for 6 h/day, 5 days/week for 13 weeks and were evaluated on a series of behavioral tests beginning 3 days after the end of exposure. Toluene delayed appetitively-motivated acquisition of a lever-press response, but did not affect motor activity, anxiety-related behavior in the elevated plus maze, trace fear conditioning, acquisition of an appetitively-motivated visual discrimination, or performance of a visual signal detection task Challenges with acute inhalation of toluene vapor (1200-2400 ppm for 1 h) and injections of quinpirole (0.01-0.03 mg/kg) and raclopride (0.03-0.10 mg/kg) revealed no toluene-induced latent impairments in visual signal detection. These results are consistent with a pattern of subtle and inconsistent long-term effects of daily exposure to toluene vapor, in contrast to robust and reliable effects of acute inhalation of the solvent. Published by Elsevier Inc.

引用

页码：611 / 619

页数：9

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