Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades?

被引：204

作者：

Abdollahi, Elham ^{[1
,2
]}

Momtazi, Amir Abbas ^{[3
]}

Johnston, Thomas P. ^{[4
]}

Sahebkar, Amirhossein ^{[1
,5
,6
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Dept Med Immunol, POB 91779-48564, Mashhad, Iran

[2] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran

[3] Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, Student Res Comm,Nanotechnol Res Ctr, Mashhad, Iran

[4] Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64110 USA

[5] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2018年 / 233卷 / 02期

关键词：

autoimmune disease; curcumin; immune system; inflammation; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; REGULATORY T-CELLS; NECROSIS-FACTOR-ALPHA; ACID-INDUCED COLITIS; FATTY LIVER-DISEASE; BREAST-CANCER CELLS; GENE-EXPRESSION; DOUBLE-BLIND; DENDRITIC CELLS;

D O I：

10.1002/jcp.25778

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Curcumin is a dietary polyphenol from turmeric with numerous pharmacological activities. Novel animal and human studies indicate that curcumin can affect different immune cells, such as various T lymphocyte subsets, macrophages, dendritic cells, B lymphocytes and natural killer cells, which results in decreasing severity of various diseases with immunological etiology. The present review provides a comprehensive overview of the effects of curcumin on different immune cells and immune system-related diseases.

引用

页码：830 / 848

页数：19

共 189 条

[1] Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review [J].