Human cytomegalovirus downregulates complement receptors (CR3, CR4) and decreases phagocytosis by macrophages

被引：16

作者：

Gafa, V

Manches, O

Pastor, A

Drouet, E

Ambroise-Thomas, P

Grillot, R

Aldebert, D

机构：

[1] Fac Med Pharm, Lab Interact Cellulaires Parasites Hote, ICPH UJF, F-38706 La Tronche, France

[2] EFS Rhone Alpes, Lab Rech & Dev, La Tronche, France

[3] Fac Med Pharm, Lab Virol Mol & Struct, UJF, F-38706 La Tronche, France

来源：

JOURNAL OF MEDICAL VIROLOGY | 2005年 / 76卷 / 03期

关键词：

Herpesviridae; innate immunity; transplant patients; opportunistic infections;

D O I：

10.1002/jmv.20358

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human cytomegalovirus (HCMV) infection is associated with an increased susceptibility to opportunistic infections. Although the subversion of adaptive immune responses has been extensively studied, the consequences of HCMV infection on natural immune responses are not well documented. A striking selective down-modulation of CD11b/CD18 (CR3) or CD11c/CD18 (CR4) was found upon HCMV infection, on two models,the monocytic THP-1 cell line and monocyte-derived macrophages. HCMV-infected macrophages have an altered adhesion/phagocytic capacity to Candida albicans, a pathogen responsible for some opportunistic infections in immunocompromised patients. These results suggest a new mechanism implicated in the augmentation of opportunistic infections in HCMV patients. (C) 2005 Wiley-Liss, Inc

引用

页码：361 / 366

页数：6

共 34 条

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