Multiwalled Carbon Nanotubules Induce Pathological Changes in the Digestive Organs of Mice

被引：6

作者：

Masyutin, A. G. ^{[1
]}

Erokhina, M. V. ^{[1
]}

Sychevskaya, K. A. ^{[1
]}

Gusev, A. A. ^{[2
]}

Vasyukova, I. A. ^{[2
]}

Tkachev, A. G. ^{[3
]}

Smirnova, E. A. ^{[1
]}

Onishchenko, G. E. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Moscow, Russia

[2] GR Derzhavin Tambov State Univ, Nanotechnol & Nanomat Res & Educ Ctr, Tambov, Russia

[3] NanoTechCenter, Tambov, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

multiwalled carbon nanotubules; enterocyte necrosis; liver degeneration; TOXICITY;

D O I：

10.1007/s10517-016-3361-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effects of regular long-term exposure to industrial nanomaterial based on multiwalled carbon nanotubules on the digestive system of mice. Nanomaterial in a concentration of 30 mg/kg was administered with drinking water over 30 days. Tissue specimens from the small intestine and liver were studied by light and electron microscopy. Multiwalled carbon nanotubules caused multiple necrotic foci in the small intestine and mixed parenchymatous degeneration in the liver. These findings suggested that multiwalled carbon nanotubules entering the digestive tract damaged intestinal villi, presumably via mechanical damage to enterocytes. It seems that multiwalled carbon nanotubules could cause degeneration indirectly, by triggering inflammatory reactions and ROS generation.

引用

页码：125 / 130

页数：6

共 10 条

[1] [Anonymous], 2012, GUIDELINES 1 2 0047
[2] Multi walled carbon nano tubes induced hepatotoxicity in Swiss albino mice
Awasthi, Kumud Kant
John, P. J.
Awasthi, Anjali
Awasthi, Kamlendra
[J]. MICRON, 2013, 44 : 359 - 364
[3] Transient oxidative stress and inflammation after intraperitoneal administration of multiwalled carbon nanotubes functionalized with single strand DNA in rats
Clichici, Simona
Biris, Alexandru Radu
Tabaran, Flaviu
Filip, Adriana
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 259 (03) : 281 - 292
[4] Pulmonary toxicity of carbon nanotubes and asbestos - Similarities and differences
Donaldson, Ken
Poland, Craig A.
Murphy, Fiona A.
MacFarlane, Marion
Chernova, Tatyana
Schinwald, Anja
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (15) : 2078 - 2086
[5] Lung Macrophages "Digest" Carbon Nanotubes Using a Superoxide/Peroxynitrite Oxidative Pathway
Kagan, Valerian E.
Kapralov, Alexandr A.
St Croix, Claudette M.
Watkins, Simon C.
Kisin, Elena R.
Kotchey, Gregg P.
Balasubramanian, Krishnakumar
Vlasova, Irina I.
Yu, Jaesok
Kim, Kang
Seo, Wanji
MallampaIli, Rama K.
Star, Alexander
Shvedova, Anna A.
[J]. ACS NANO, 2014, 8 (06) : 5610 - 5621
[6] Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity
Manke, Amruta
Wang, Liying
Rojanasakul, Yon
[J]. BIOMED RESEARCH INTERNATIONAL, 2013, 2013
[7] Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis
Roberts, Ruth A.
Ganey, Patricia E.
Ju, Cynthia
Kamendulis, Lisa M.
Rusyn, Ivan
Klaunig, James E.
[J]. TOXICOLOGICAL SCIENCES, 2007, 96 (01) : 2 - 15
[8] Multi-walled Carbon Nanotubes Penetrate into Plant Cells and Affect the Growth of Onobrychis arenaria Seedlings
Smirnova, E. A.
Gusev, A. A.
Zaitseva, O. N.
Lazareva, E. M.
Onishchenko, G. E.
Kuznetsova, E. V.
Tkachev, A. G.
Feofanov, A. V.
Kirpichnikov, M. P.
[J]. ACTA NATURAE, 2011, 3 (01): : 99 - 106
[9] Tkachev A. G., 2007, EQUIPMENT TECHNOLOGY
[10] Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice
Wang, Xiaojia
Katwa, Pranita
Podila, Ramakrishna
Chen, Pengyu
Ke, Pu Chun
Rao, Apparao M.
Walters, Dianne M.
Wingard, Christopher J.
Brown, Jared M.
[J]. PARTICLE AND FIBRE TOXICOLOGY, 2011, 8

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