Genetic selection for susceptibility to oral tolerance leads to a profound reduction of the acute inflammatory response

被引：6
作者：
Da Silva, MDS
Da Nóbrega, A
Barja-Fidalgo, TC
Brando-Lima, AC
Cunha, F
Da Silva, AC
机构：
[1] UERJ, Inst Biol, Dept Biol Celular & Genet, Lab Imunobiol,PHLC, BR-20559900 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Dept Imunol, Rio De Janeiro, Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Sao Paulo, Brazil
来源：
ORAL TOLERANCE: NEW INSIGHTS AND PROSPECTS FOR CLINICAL APPLICATION | 2004年 / 1029卷
关键词：
oral tolerance; genetic selection; ovalbumin; acute inflammation; neutrophils; IL-1; IL-10; IL-12; TNF; LPS; corticoid; prostaglandin;
D O I：
10.1196/annals.1309.024
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Strains of mice obtained by genetic selection to extremes of phenotype for susceptibility or resistance to oral tolerance were investigated for possible genetic correlations with acute inflammatory response using different models of inflammation. The results show a strong genetic association.
引用
收藏
页码：398 / 401
页数：4
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