Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases

被引:150
作者
Grillo, M. A. [1 ]
Colombatto, S. [1 ]
机构
[1] Univ Turin, Sez Biochim, Dipartimento Med & Oncol Sperimentale, I-10126 Turin, Italy
关键词
RAGE; TAGE; detoxification; amadorines;
D O I
10.1007/s00726-007-0606-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Advanced glycation end-products (AGEs) are formed from the so-called Amadori products by rearrangement followed by other reactions giving rise to compounds bound irreversibly. The structure of some of them is shown and the mechanism of formation is described. Several AGE binding molecules (Receptors for AGE, RAGE) are known and it is thought that many of the effects caused by AGEs are mediated by RAGE. Some of these were shown to be toxic, and called TAGE. The mechanism of detoxification of glyoxal and methylglyoxal by the glyoxalase system is described and also the possibility to eliminate glycated proteins by deglycation enzymes. Compounds able to inhibit AGEs formation are also taken into consideration.
引用
收藏
页码:29 / 36
页数:8
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