A nationwide survey of the association between nonalcoholic fatty liver disease and the incidence of asthma in Korean adults

被引:13
作者
Roh, Jae-Hyung [1 ]
Lee, Hanbyul [2 ]
Yun-Jeong, Bae [3 ]
Park, Chan Sun [4 ]
Kim, Hyo-Jung [5 ]
Yoon, Sun-Young [6 ]
机构
[1] Chungnam Natl Univ, Chungnam Natl Univ Sejong Hosp, Sch Med, Dept Cardiol Internal Med, Sejong, South Korea
[2] Kyungpook Natl Univ, Dept Stat, Daegu, South Korea
[3] Asan Med Ctr, Asan Inst Life Sci, Hlth Innovat Bigdata Ctr, Seoul, South Korea
[4] Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea
[5] INJE Haeundae Paik Hosp, Div Pulmonol, Dept Internal Med, Busan, South Korea
[6] Chungnam Natl Univ, Chungnam Natl Univ Sejong Hosp, Dept Allergy & Pulmonol Internal Med, Sejong, South Korea
关键词
BODY-MASS INDEX; METABOLIC SYNDROME; OBESITY; PREVALENCE; RISK; METAANALYSIS; MORTALITY;
D O I
10.1371/journal.pone.0262715
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Asthma and nonalcoholic fatty liver disease (NAFLD) are chronic diseases known to be associated with metabolic abnormalities. We aimed to clarify the association between NAFLD and asthma incidence in a large population-based cohort. Methods and findings We selected 160,603 individuals without comorbidities from the National Health Insurance Service-National Sample cohort between 2009 and 2014. NAFLD was defined using a surrogate marker, fatty liver index (FLI). During a median of 5.08 years' follow-up, 16,377 subjects (10.2%) were newly diagnosed with asthma and categorized into three groups according to FLI. The cumulative incidence of asthma was higher in subjects with higher vs. lower FLIs (FLI < 30, 10.1%; 30 <= FLI < 60, 10.8%; FLI >= 60, 10.5%). Higher FLI was associated with an increased incidence of asthma (Hazard ratios (HR)(highest vs. lowest FLI), 1.25; 95% CI, 1.15-1.36). The results using another definition of NAFLD, as measured by the hepatic steatosis index (HSI), were similar to the primary results. This association was more pronounced in women than in men (HR 1.46; 95% CI, 1.13-1.64 vs. HR 1.07; 95% CI, 0.94-1.20). Conclusions This study demonstrated that NAFLD, as measured by FLI and HSI, may influence the incidence rates of asthma in adults, especially in women.
引用
收藏
页数:13
相关论文
共 44 条
[11]   Insulin-Induced Laminin Expression Promotes a Hypercontractile Airway Smooth Muscle Phenotype [J].
Dekkers, Bart G. J. ;
Schaafsma, Dedmer ;
Tran, Thai ;
Zaagsma, Johan ;
Meurs, Herman .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2009, 41 (04) :494-504
[12]   Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children [J].
Han, Yueh-Ying ;
Forno, Erick ;
Celedon, Juan C. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 190 (01) :32-39
[13]   Validation of the Fatty Liver Index for Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Chinese [J].
Huang, Xiaolin ;
Xu, Min ;
Chen, Ying ;
Peng, Kui ;
Huang, Ya ;
Wang, Po ;
Ding, Lin ;
Lin, Lin ;
Xu, Yu ;
Chen, Yuhong ;
Lu, Jieli ;
Wang, Weiqing ;
Bi, Yufang ;
Ning, Guang .
MEDICINE, 2015, 94 (40)
[14]   Factors associated to lifestyle and risk of adult onset asthma [J].
Huovinen, E ;
Kaprio, J ;
Koskenvuo, M .
RESPIRATORY MEDICINE, 2003, 97 (03) :273-280
[15]   Risk factors of asthma exacerbation based on asthma severity: a nationwide population-based observational study in South Korea [J].
Kang, Hye-Rim ;
Song, Hyun Jin ;
Nam, Jin Hyun ;
Hong, Sung-Hyun ;
Yang, So-Young ;
Ju, SangEun ;
Lee, Sang Won ;
Kim, Tae-Bum ;
Kim, Hye-Lin ;
Lee, Eui-Kyung .
BMJ OPEN, 2018, 8 (03)
[16]  
KIM JJ, 2020, SCI REP-UK, V10, DOI DOI 10.1038/S41598-020-63846-3
[17]   Sex-race differences in the relationship between obesity and asthma: The Behavioral Risk Factor Surveillance System, 2000 [J].
Kim, S ;
Camargo, CA .
ANNALS OF EPIDEMIOLOGY, 2003, 13 (10) :666-673
[18]   Coexisting COPD Increases Mortality in Patients With Corticosteroid-Dependent Asthma: A Nationwide Population-Based Study [J].
Lee, Hyun ;
Ryu, Jiin ;
Chung, Sung Jun ;
Park, Dong Won ;
Sohn, Jang Won ;
Yoon, Ho Joo ;
Kim, Sang-Heon .
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2020, 12 (05) :821-831
[19]  
Lee T, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0112844, DOI 10.1371/J0URNAL.P0NE.0112844]
[20]   Lung Function Impairment and Metabolic Syndrome The Critical Role of Abdominal Obesity [J].
Leone, Nathalie ;
Courbon, Dominique ;
Thomas, Frederique ;
Bean, Kathy ;
Jego, Bertrand ;
Leynaert, Benedicte ;
Guize, Louis ;
Zureik, Mahmoud .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179 (06) :509-516