Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus

被引：53

作者：

Dong, Fangfang ^{[1
,2
]}

Li, Dandan ^{[1
,2
]}

Wen, Dan ^{[1
,2
]}

Li, Suhua ^{[1
,2
]}

Zhao, Chaoyue ^{[1
,2
]}

Qi, Yue ^{[1
]}

Jangra, Rohit K. ^{[3
]}

Wu, Cuiping ^{[4
]}

Xia, Dequan ^{[4
]}

Zhang, Xing ^{[2
]}

Deng, Fei ^{[2
,5
]}

Chandran, Kartik ^{[3
]}

Zou, Zhen ^{[1
,2
]}

Yuan, Fei ^{[6
]}

Zheng, Aihua ^{[1
,2
,7
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA

[4] Yidu Cent Hosp Weifang, Dept Infect Dis, Weifang, Peoples R China

[5] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China

[6] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China

[7] Henan Normal Univ, Coll Life Sci, Xinxiang, Peoples R China

来源：

NPJ VACCINES | 2019年 / 4卷 / 1期

关键词：

ENTRY REQUIRES; SOUTH-KOREA; INFECTION; IMMUNOGENICITY; IDENTIFICATION; PATHOGENESIS; BUNYAVIRUS; ANTIBODIES; SAFETY; CHINA;

D O I：

10.1038/s41541-018-0096-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe fever with thrombocytopenia virus (SFTSV) is an emerging tick-borne phlebovirus that causes lethal human disease, for which there are no licensed antiviral vaccines or therapies. Herein, we developed a live attenuated recombinant vesicular stomatitis virus (rVSV)-based vaccine candidate expressing the SFTSV Gn/Gc glycoproteins (rVSV-SFTSV/AH12-GP). High titers of cross-protective, broadly neutralizing antibodies were elicited by a single dose of rVSV-SFTSV/AH12-GP in both immunocompetent and immunocompromised mice against multiple strains of SFTSV and the related but distinct phlebovirus Heartland virus (HRTV). Remarkably, complete protection against lethal challenge with SFTSV was conferred in young and old immunocompromised mice irrespective of any pre-existing vector-specific immunity. Collectively, these results suggest that a rVSV vector expressing SFTSV glycoproteins is a promising candidate vaccine against two emerging phleboviruses associated with severe human diseases.

引用

页数：11

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