Therapeutic drug monitoring in the treatment of tuberculosis patients

被引：53

作者：

Magis-Escurra, Cecile ^{[1
]}

van den Boogaard, Jossy ^{[1
]}

IJdema, Dirk ^{[1
]}

Boeree, Martin ^{[1
]}

Aarnoutse, Rob ^{[2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Univ Ctr Chron Dis Dekkerswald, NL-6561 KE Groesbeek, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Pharm, NL-6525 ED Nijmegen, Netherlands

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2012年 / 25卷 / 01期

关键词：

Therapeutic drug monitoring; Tuberculosis; ANTITUBERCULOSIS DRUGS; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; BACTERICIDAL ACTIVITY; SERUM-LEVELS; PHARMACOKINETICS; RIFAMPIN; RESISTANCE; PHARMACODYNAMICS; PYRAZINAMIDE;

D O I：

10.1016/j.pupt.2011.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

At the University Centre for Chronic Diseases Dekkerswald, a tertiary tuberculosis (TB) referral hospital in The Netherlands, therapeutic drug monitoring (TDM) is used in patients in case of relapse TB, when there is delayed response to TB treatment, and when abnormal TB drug concentrations are suspected for other reasons. In this article, a case series is presented to illustrate the value of individualized TB drug dosing in four patients with low TB drug concentrations. Increased doses of the TB drugs, especially of rifampicin, resulted in adequate peak plasma concentrations and improved clinical response to treatment in these patients, while no adverse events occurred. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：83 / 86

页数：4

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