Influence of membrane ion channel in pituitary somatotrophs by hypothalamic regulators

被引：8

作者：

Yang, Seung-Kwon ^{[1
]}

Steyn, Frederik ^{[1
]}

Chen, Chen ^{[1
]}

机构：

[1] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

来源：

CELL CALCIUM | 2012年 / 51卷 / 3-4期

关键词：

Growth hormone; Ion channels; Somatotroph; GHRH; SRIF; Ghrelin; GROWTH-HORMONE-SECRETION; VOLTAGE-GATED CA2+; ACTIVATED POTASSIUM CURRENTS; CA2+-ACTIVATED K+ CHANNEL; UNION-OF-PHARMACOLOGY; GH-RELEASING HORMONE; CALCIUM-CHANNELS; MULTIPLE TYPES; MOLECULAR RELATIONSHIPS; CHLORIDE CHANNELS;

D O I：

10.1016/j.ceca.2011.12.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The secretion of growth hormone (GH) from somatotrophs located within the anterior pituitary gland is stimulated by endogenous hypothalamic growth hormone-releasing hormone (GHRH) and the GH secretagogue (GHS) ghrelin, and inhibited by somatotropin-releasing inhibitory factor (SRIF, also known as somatostatin). These factors bind to specific G-protein-coupled receptors on the cell membrane, and directly or indirectly modify the properties of ion channels and second messenger systems. Ultimately this results in a change in intracellular free Ca2+ concentration ([Ca2+](i)) and the secretion of GH. Somatotrophs possess a variety of ion channels on their membranes, and modification of these ion channels, especially Ca2+, K+, and Na+ channels, is tightly linked to intracellular Ca2+ levels and therefore hormone secretion. Various issues regarding receptor distribution, role of ion channels, alteration of membrane potential, and involvement of intracellular signaling system in the control of GH secretion are discussed in this review. In particular, this work will focus on ion channels and [Ca2+] in somatotrophs. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：231 / 239

页数：9

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