Driving force of COVID-19 among people living with HIV in Wuhan, China

被引:4
作者
Guo, Wei [1 ,2 ]
Ming, Fangzhao [3 ]
Dong, Yu [4 ]
Zhang, Qian [5 ]
Liu, Lian [6 ]
Gao, Ming [7 ]
Zhang, Xiaoxia [8 ]
Mo, Pingzheng [8 ]
Feng, Yong [9 ]
Tang, Weiming [10 ,11 ]
Liang, Ke [8 ,12 ,13 ,14 ]
机构
[1] Wuhan Univ, Dept Pathol, Zhongnan Hosp, Wuhan, Peoples R China
[2] Wuhan Univ, Dept Pathol, Sch Basic Med Sci, Wuhan, Peoples R China
[3] Wuchang Dist Ctr Dis Control & Prevent, Wuhan, Peoples R China
[4] Wuhan Univ, Dept Geriatr, Zhongnan Hosp, Wuhan, Peoples R China
[5] Qingshan Dist Ctr Dis Control & Prevent, Wuhan, Peoples R China
[6] Caidian Dist Ctr Dis Control & Prevent, Wuhan, Peoples R China
[7] Xinzhou Dist Ctr Dis Control & Prevent, Wuhan, Peoples R China
[8] Wuhan Univ, Dept Infect Dis, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
[9] Wuhan Univ, Sch Basic Med Sci, Dept Med Microbiol, Wuhan 430071, Peoples R China
[10] Southern Med Univ, Dermatol Hosp, Guangzhou, Peoples R China
[11] Univ North Carolina Chapel Hill Project China, Guangzhou 510095, Peoples R China
[12] Wuhan Univ, Dept Nosocomial Infect Management, Zhongnan Hosp, Wuhan, Hubei, Peoples R China
[13] Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan, Peoples R China
[14] Hubei Engn Ctr Infect Dis Prevent Control & Treat, Wuhan, Peoples R China
来源
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV | 2022年 / 34卷 / 11期
关键词
COVID-19; People living with HIV (PLWH); morbidity; risk factor;
D O I
10.1080/09540121.2022.2052259
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background: Although people living with HIV (PLWH) were considered to be at increased risk of SARS-CoV-2 infection, the driving force among this group of individuals is still not clear. Methods: We investigated 1,709 PLWH through a telephone interview and identified 11 COVID-19 patients in four districts of Wuhan, China. The demographic features and major clinical characteristics of these patients were retrieved from the information management systems for COVID-19 patients of the four districts' CDC. Statistical analysis was performed to find out the driving force of COVID-19 among PLWH. Results: The prevalence of COVID-19 in PLWH is 0.6% (95% CI: 0.2% - 1.0%), which is comparable to the overall population prevalence in Wuhan city (0.6%). Nine out of the 11 COVID-19 patients had relatively high CD4+ T lymphocyte count (>200/mu l) and undetectable HIV viral load (<20 copies/ml), and ten of them were on antiretroviral therapy. Older PLWH with low CD4 + count, got HIV infected through homosexual activity, and had been diagnosed with HIV for a long time, were more likely to develop COVID-19. Conclusions: COVID-19 related morbidity rates were comparable between PLWH and the general population. Older age with low CD4 count, an extended period of HIV diagnosis, and treatment-naivety were potential driving forces of COVID-19 prevalence among PLWH. Strategies for preventing SARS-CoV-2 infection among PLWH with weak immune responses are required.
引用
收藏
页码:1364 / 1371
页数:8
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