Development of Chiral Spiro P-N-S Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of -Alkyl--Ketoesters

被引：73

作者：

Bao, Deng-Hui ^{[1
,2
]}

Wu, Hui-Ling ^{[1
,2
]}

Liu, Chao-Lun ^{[1
,2
]}

Xie, Jian-Hua ^{[1
,2
]}

Zhou, Qi-Lin ^{[1
,2
]}

机构：

[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 30期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; hydrogenation; iridium; ketoesters; spiro ligands; HIGHLY ENANTIOSELECTIVE HYDROGENATION; MINIMALLY FUNCTIONALIZED OLEFINS; PHOSPHORUS LIGANDS; AMINOPHOSPHINE LIGANDS; DIPHOSPHINE LIGANDS; BETA-KETOESTERS; NOBEL LECTURE; GROUP LEADS; KETONES; COMPLEXES;

D O I：

10.1002/anie.201502860

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chiral tridentate spiro P-N-S ligands (SpiroSAP) were developed, and their iridium complexes were prepared. Introduction of a 1,3-dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asymmetric hydrogenation of -alkyl--ketoesters, producing chiral -alkyl--hydroxyesters with excellent enantioselectivities (95-99.9% ee) and turnover numbers of up to 355000.

引用

页码：8791 / 8794

页数：4

共 52 条

[1]

Andrushko V., 2013, STEREOSELECTIVE SYNT, P909

[2]

[Anonymous], 2007, The Handbook of Homogeneous Hydrogenation

[3]

[Anonymous], 2013, Angew. Chem., Int. Ed.

[4] Chiral P,N-ligands with pyridine-nitrogen and phosphorus donor atoms.: Syntheses and applications in asymmetric catalysis [J].