Role of epigenetics and DNA-damage in asthma

被引：11

作者：

Zahiruddin, Adil S. ^{[1
]}

Grant, J. Andrew ^{[1
]}

Sur, Sanjiv ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Internal Med, Div Allergy & Immunol, Galveston, TX 77555 USA

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2018年 / 18卷 / 01期

关键词：

asthma; DNA-damage; epigenetics; CHILDHOOD ASTHMA; PUERTO-RICAN; HAY-FEVER; GENE; METHYLATION; EXPRESSION; REPAIR; HERITABILITY; INFLAMMATION; MECHANISMS;

D O I：

10.1097/ACI.0000000000000415

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Purpose of reviewAlthough asthma is a common disease worldwide, its pathogenesis remains to be fully elucidated. There is increasing evidence of the interaction between epigenetics, DNA-damage, and environmental allergens in the development of asthma. In this review, we will focus on the role of epigenetics and DNA-damage in asthma.Recent findingsThere is growing evidence of environmental allergens, particularly house dust mite, stimulating oxidative DNA damage in airway epithelial cells. The repair of this DNA damage has been implicated in the secretion of Th2 cytokines and the induction of allergic inflammation.SummaryStudies of the role of epigenetics, DNA-damage, and environmental allergens have begun to reveal the their complex interactions and their roles in the development of asthma. Further study in these areas may lead to novel prevention and treatment approaches.

引用

页码：32 / 37

页数：6

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