The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis

被引：31
作者：
Han, Jinju [1 ]
Denli, Ahmet M. [1 ]
Gage, Fred H. [1 ]
机构：
[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA
来源：
GENES & DEVELOPMENT | 2012年 / 26卷 / 01期
关键词：
miR-26b; ctdsp2; REST; neurogenesis; neuronal differentiation; zebrafish; POSTTRANSCRIPTIONAL REGULATION; MICRORNA BIOGENESIS; REST; TRANSCRIPTION; EXPRESSION; REVEALS; LIN28; IDENTIFICATION; URIDYLATION; RECOGNITION;
D O I：
10.1101/gad.184416.111
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Differentiation of multipotent stem cells occurs through the highly coordinated control of gene expression. Repressor element 1 (RE1) silencing transcription factor (REST), a master transcriptional regulator in neuronal stem cells, restricts neuronal gene expression. REST activity is context-dependent and is modified by its cofactors, such as Ctdsp2. In this issue of Genes & Development, Dill and colleagues (pp. 25-30) report on the microRNA-mediated regulation of neural differentiation. Interestingly, this microRNA is post-transcriptionally regulated and modulates expression of its host gene, ctdsp2.
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页码：6 / 10
页数：5
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