An Approach to the Diastereoselective Synthesis of Cyclohexane-1,3-dicarboxamide Derivatives via a Pseudo Five-Component Reaction Based on Diketene

被引：16
作者：
Talaei, Bahareh [1 ]
Heravi, Majid M. [1 ]
Oskooie, Hossein A. [1 ]
Rezvanian, Atieh [1 ]
机构：
[1] Alzahra Univ, Phys & Chem Fac, Tehran, Iran
来源：
SYNLETT | 2018年 / 29卷 / 02期
基金：
美国国家科学基金会;
关键词：
diketene; cyclohexanone; multicomponent reaction; one-pot reaction; diastereoselective synthesis; BETA-KETO-ESTERS; ONE-POT; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; 4-COMPONENT REACTION; 3-COMPONENT REACTION; AROMATIC-ALDEHYDES; EFFICIENT; GREEN; FORMALDEHYDE;
D O I：
10.1055/s-0036-1590980
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot pseudo five-component reaction for the synthesis of 2-aryl-4-hydroxy-4-methyl-6-oxo-N-1, N-3-dialkylcyclohexane-1,3-dicarboxamide derivatives involving different primary amines, various aromatic aldehydes, and diketene in the presence of triethylamine with high yields is achieved.
引用
收藏
页码：225 / 229
页数：5
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