An Approach to the Diastereoselective Synthesis of Cyclohexane-1,3-dicarboxamide Derivatives via a Pseudo Five-Component Reaction Based on Diketene

被引：16

作者：

Talaei, Bahareh ^{[1
]}

Heravi, Majid M. ^{[1
]}

Oskooie, Hossein A. ^{[1
]}

Rezvanian, Atieh ^{[1
]}

机构：

[1] Alzahra Univ, Phys & Chem Fac, Tehran, Iran

来源：

SYNLETT | 2018年 / 29卷 / 02期

基金：

美国国家科学基金会;

关键词：

diketene; cyclohexanone; multicomponent reaction; one-pot reaction; diastereoselective synthesis; BETA-KETO-ESTERS; ONE-POT; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; 4-COMPONENT REACTION; 3-COMPONENT REACTION; AROMATIC-ALDEHYDES; EFFICIENT; GREEN; FORMALDEHYDE;

D O I：

10.1055/s-0036-1590980

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot pseudo five-component reaction for the synthesis of 2-aryl-4-hydroxy-4-methyl-6-oxo-N-1, N-3-dialkylcyclohexane-1,3-dicarboxamide derivatives involving different primary amines, various aromatic aldehydes, and diketene in the presence of triethylamine with high yields is achieved.

引用

页码：225 / 229

页数：5

共 61 条

[1] One-pot synthesis of 4,5-dihydro-1H-pyrrol-3-carboxamide derivatives via a four-component reaction [J].