Lessons from yeast for clathrin-mediated endocytosis

被引:88
作者
Boettner, Douglas R. [1 ]
Chi, Richard J. [1 ]
Lemmon, Sandra K. [1 ]
机构
[1] Univ Miami, Miller Sch Med, Dept Mol & Cellular Pharmacol R 189, Miami, FL 33101 USA
基金
美国国家卫生研究院;
关键词
CORTICAL ACTIN CYTOSKELETON; SERINE/THREONINE KINASE PRK1P; CHAIN-DEFICIENT YEAST; F-BAR PROTEINS; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; VESICLE FORMATION; COATED VESICLES; LIGHT-CHAIN; IN-VIVO;
D O I
10.1038/ncb2403
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.
引用
收藏
页码:2 / 10
页数:9
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