Lessons from yeast for clathrin-mediated endocytosis

被引：87

作者：

Boettner, Douglas R. ^{[1
]}

Chi, Richard J. ^{[1
]}

Lemmon, Sandra K. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Mol & Cellular Pharmacol R 189, Miami, FL 33101 USA

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CORTICAL ACTIN CYTOSKELETON; SERINE/THREONINE KINASE PRK1P; CHAIN-DEFICIENT YEAST; F-BAR PROTEINS; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; VESICLE FORMATION; COATED VESICLES; LIGHT-CHAIN; IN-VIVO;

D O I：

10.1038/ncb2403

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

引用

页码：2 / 10

页数：9

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