The effects of Ginsenosides on PI3K/AKT signaling pathway

被引：11

作者：

Ghafouri-Fard, Soudeh ^{[1
]}

Balaei, Neda ^{[2
]}

Shoorei, Hamed ^{[3
]}

Hasan, Syed Muhammad Farid ^{[4
]}

Hussen, Bashdar Mahmud ^{[5
]}

Talebi, Seyedeh Fahimeh ^{[6
]}

Taheri, Mohammad ^{[7
]}

Ayatollahi, Seyed Abdulmajid ^{[8
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[2] Tabriz Univ Med Sci, Dept Pharmacol, Tabriz, Iran

[3] Birjand Univ Med Sci, Fac Med, Dept Anat Sci, Birjand, Iran

[4] Univ Karachi, Fac Pharm & Pharmaceut Sci, Dept Pharmaceut, Karachi, Pakistan

[5] Hawler Med Univ, Coll Pharm, Dept Pharmacognosy, Kurdistan Region, Iraq

[6] Birjand Univ Med Sci, Coll Pharm, Dept Pharmacol, Birjand, Iran

[7] Jena Univ Hosp, Inst Human Genet, Jena, Germany

[8] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran

来源：

MOLECULAR BIOLOGY REPORTS | 2022年 / 49卷 / 07期

关键词：

Ginsenoside; Gene expression; Signaling pathway; CELL-CYCLE ARREST; ANTICANCER ACTIVITY; INDUCED APOPTOSIS; HEPATOCELLULAR-CARCINOMA; 20(S)-GINSENOSIDE RG3; MOLECULAR-MECHANISMS; PANCREATIC-CANCER; OXIDATIVE STRESS; DOWN-REGULATION; MODULATING AKT;

D O I：

10.1007/s11033-022-07270-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ginsenosides belong to a group of steroid glycosides that are extracted from the plant genus Panax (ginseng). This plant has been used for a long time for the treatment of a variety of disorders in traditional medicine. Recent studies have assessed the biological impact of Ginsenosides in cell culture or animal models. Animal studies have shown their beneficial impacts in the remedy of pathological conditions in different tissues. The ameliorating effects of Ginsenosides in diverse pathogenic conditions can be attributed to their effects on the production of reactive oxygen species. These substances mainly affect the activity of AMPK/AKT and PI3K/AKT pathways. The beneficial effects of Ginsenosides have been appraised in diabetes-related complications, spinal cord injury, cerebral ischemia, myocardial ischemia, and other disorders which are associated with oxidative stress. Moreover, these substances have been shown to interfere with the pathologic conditions during carcinogenesis. In the current study, we explain these impacts in two distinct sections including non-neoplastic conditions and neoplastic conditions.

引用

页码：6701 / 6716

页数：16

共 70 条

[1] Ginsenoside Rb1 prevents hypoxia-reoxygenation-induced apoptosis in H9c2 cardiomyocytes via an estrogen receptor-dependent crosstalk among the Akt, JNK, and ERK 1/2 pathways using a label-free quantitative proteomics analysis [J].