Parkinson's disease: The non-motor issues

被引：285

作者：

Chaudhuri, K. Ray ^{[1
]}

Odin, Per ^{[2
,3
]}

Antonini, Angelo ^{[4
]}

Martinez-Martin, Pablo ^{[5
,6
]}

机构：

[1] Kings Coll London, Kings Coll Hosp, Natl Parkinson Fdn, Ctr Excellence, London SE5 9RS, England

[2] Cent Hosp, Dept Neurol, Bremerhaven, Germany

[3] Univ Hosp, Dept Neurol, Lund, Sweden

[4] Venice & Univ Padua, IRCCS San Camillo, Padua, Italy

[5] Alzheimer Ctr Reina Sofia Fdn, AD Res Unit, Madrid, Spain

[6] Alzheimer Ctr Reina Sofia Fdn, CIBERNED, CIEN Fdn, Carlos III Inst Hlth, Madrid, Spain

来源：

PARKINSONISM & RELATED DISORDERS | 2011年 / 17卷 / 10期

关键词：

Non-motor symptoms; Parkinson's disease; Non-motor off period; NMSQuest; QUALITY-OF-LIFE; SYMPTOMS QUESTIONNAIRE; SYDNEY MULTICENTER; DYSFUNCTION; FLUCTUATIONS; PROGRESSION; DEPRESSION; DISORDER; INFUSION; IMPACT;

D O I：

10.1016/j.parkreldis.2011.02.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Non-motor symptoms (NMS) of Parkinson's disease remain the most under-appreciated and under-researched when taken as a whole. Data is emerging that it is the "totaL" burden of NMS that is the major determinant of quality of life not a single NMS such as depression for instance. Only recently validated tools such as the NMSQuest which empowers patients to declare NMS and the NMS scale, the SCOPA scales, and the modified version of the MDS-UPDRS have become available and validated for bedside clinical assessment of NMS. For the first time clinical trials have been incorporating non-motor measures as outcome measures and clinical recommendations for treatment of non-motor symptoms of PD are being published. This review aims to address some of these topical and "real life" aspects of modern day management of Parkinson's. (C) 2011 Published by Elsevier Ltd.

引用

页码：717 / 723

页数：7

共 55 条

[1] Frequency of bowel movements and the future risk of Parkinson's disease [J].

Abbott, RD ;

Petrovitch, H ;

White, LR ;

Masaki, KH ;

Tanner, CM ;

Curb, JD ;

Grandinetti, A ;

Blanchette, PL ;

Popper, JS ;

Ross, GW .

NEUROLOGY, 2001, 57 (03) :456-462

[2] Epidemiology of Parkinson's disease [J].

Alves, Guido ;

Forsaa, Elin Bjelland ;

Pedersen, Kenn Freddy ;

Gjerstad, Michaela Dreetz ;

Larsen, Jan Petter .

JOURNAL OF NEUROLOGY, 2008, 255 (Suppl 5) :18-32

[3]

[Anonymous], PARKINSONISM RELAT D

[4]

[Anonymous], PARKINSONISM RELAT D

[5]

[Anonymous], NONMOTOR SYMPTOMS PA

[6]

[Anonymous], PARKINSONISM RELAT D

[7]

[Anonymous], NEUROLOGY

[8] The Priamo Study: A Multicenter Assessment of Nonmotor Symptoms and Their Impact on Quality of Life in Parkinson's Disease [J].

Barone, Paolo ;

Antonini, Angelo ;

Colosimo, Carlo ;

Marconi, Roberto ;

Morgante, Letterio ;

Avarello, Tania P. ;

Bottacchi, Eugenio ;

Cannas, Antonino ;

Ceravolo, Gabriella ;

Ceravolo, Roberto ;

Cicarelli, Giulio ;

Gaglio, Roberto M. ;

Giglia, Rosa M. ;

Iemolo, Francesco ;

Manfredi, Michela ;

Meco, Giuseppe ;

Nicoletti, Alessandra ;

Pederzoli, Massimo ;

Petrone, Alfredo ;

Pisani, Antonio ;

Ponfieri, Francesco E. ;

Quatrale, Rocco ;

Ramat, Silvia ;

Scala, Rosanna ;

Volpe, Giuseppe ;

Zappulla, Salvatore ;

Bentivoglio, Anna Rita ;

Stocchi, Fabrizio ;

Trianni, Giorgio ;

Del Dotto, Paolo .

MOVEMENT DISORDERS, 2009, 24 (11) :1641-1649

[9] Staging of brain pathology related to sporadic Parkinson's disease [J].

Braak, H ;

Del Tredici, K ;

Rüb, U ;

de Vos, RAI ;

Steur, ENHJ ;

Braak, E .

NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211

[10] LATE PROGRESSION OF POST-ENCEPHALITIC PARKINSONS SYNDROME [J].

CALNE, DB ;

LEES, AJ .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1988, 15 (02) :135-138

← 1 2 3 4 5 6 →