Two Pairs of Epimeric Indole Alkaloids from Catharanthus roseus

被引：7

作者：

Wang, Guo-Cai ^{[1
,2
]}

Zhong, Xiang-Zhan ^{[1
,2
]}

Zhang, Dong-Mei ^{[1
,2
]}

Wang, Ying ^{[1
,2
]}

Zhang, Xiao-Qi ^{[1
,2
]}

Jiang, Ren-Wang ^{[1
,2
]}

Li, Yao-Lan ^{[1
,2
]}

Wang, Jiao ^{[1
,2
]}

Yao, Xin-Sheng ^{[1
,2
]}

Ye, Wen-Cai ^{[1
,2
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

来源：

PLANTA MEDICA | 2011年 / 77卷 / 15期

基金：

中国国家自然科学基金;

关键词：

Catharanthus roseus; Apocynaceae; indole alkaloid; cytotoxic activity; HepG2; cells; VINCA ALKALOIDS; CELL-PROLIFERATION; VINORELBINE; VINBLASTINE; VINFLUNINE; INHIBITION; MECHANISM;

D O I：

10.1055/s-0030-1271064

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two pairs of epimeric indole alkaloids (1-4) with a chlorine atom were isolated from the aerial part of Catharanthus roseus. Their structures were established on the basis of the spectroscopic data including UV, IR, HRESIMS, NMR, and X-ray diffraction analyses. The cytotoxic activities of 1-4 against the HepG2 cell line were evaluated.

引用

页码：1739 / 1741

页数：3

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