The association between body mass index and pathological complete response in neoadjuvant-treated breast cancer patients

被引:0
作者
Skarping, Ida [1 ,2 ]
Blaabjerg Pedersen, Stine [3 ]
Fornvik, Daniel [4 ]
Zackrisson, Sophia [5 ,6 ]
Borgquist, Signe [1 ,3 ]
机构
[1] Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden
[2] Skane Univ Hosp, Dept Clin Physiol & Nucl Med, Barngatan 4, S-22185 Lund, Sweden
[3] Aarhus Univ, Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark
[4] Lund Univ, Skane Univ Hosp, Dept Translat Med, Med Radiat Phys, Malmo, Sweden
[5] Lund Univ, Skane Univ Hosp, Dept Imaging & Funct Med, Diagnost Radiol,Dept Translat Med, Lund, Sweden
[6] Lund Univ, Skane Univ Hosp, Dept Imaging & Funct Med, Diagnost Radiol,Dept Translat Med, Malmo, Sweden
关键词
Breast neoplasm; body constitution; BMI; obesity; neoadjuvant chemotherapy; POOLED ANALYSIS; EARLY-STAGE; CHEMOTHERAPY; OBESITY; RISK; METAANALYSIS; OVERWEIGHT; SURVIVAL; WOMEN; BIAS;
D O I
10.1080/0284186X.2022.2055976
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Obesity seems to be associated with a poorer response to adjuvant chemotherapy in breast cancer (BC); however, associations in the neoadjuvant chemotherapy (NACT) setting and according to menopausal status are less studied. This study aims to investigate the association between pretreatment body mass index (BMI) and pathological complete response (pCR) following NACT in BC according to menopausal and estrogen receptor (ER) status. Material and Methods The study cohort consisted of 491 patients receiving NACT in 2005-2019. Based on pre-NACT patient and tumor characteristics, the association between BMI and achieving pCR was analyzed using logistic regression models (crude and adjusted models (age, tumor size, and node status)) with stratification by menopausal and ER status. Results In the overall cohort, being overweight (BMI >= 25) compared by being normal-weight (BMI <25), increased the odds of accomplishing pCR by 15%. However, based on the 95% confidence interval (CI) the data were compatible with associations within the range of a decrease of 30% to an increase of 89%. Stratification according to menopausal status also showed no strong association: the odds ratio (OR) of accomplishing pCR in overweight premenopausal patients compared with normal-weight premenopausal patients was 1.76 (95% CI 0.88-3.55), whereas for postmenopausal patients the corresponding OR was 0.71 (95% CI 0.35-1.46). Discussion In a NACT BC cohort of 491 patients, we found no evidence of high BMI as a predictive factor of accomplishing pCR, neither in the whole cohort nor stratified by menopausal status. Given the limited precision in our results, larger studies are needed before considering BMI in clinical decision-making regarding NACT or not.
引用
收藏
页码:731 / 737
页数:7
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