Visible-light-induced, autopromoted nickel-catalyzed three-component arylsulfonation of 1,3-enynes and mechanistic in-sights

A light-induced, nickel-catalyzed three-component arylsulfonation of 1,3-enynes in the absence of photocatalyst is reported. This methodology exhibited mild conditions, broad scope and high efficiency, and its synthetic utility has been demonstrated by a concise total synthesis of sulfone-containing drug molecule. Detailed mechanistic studies indicated that this light induced nickel catalysis is autopromoted by in situ produced allene, which plays a key role as co-ligand in the photoactive excited state Ni(I) species for the LMCT process. The detailed elucidation of this light-induced nickel catalytic cycle may shed some lights on the exploitation of new catalytic activity and establishment of novel methods.