Effects of fluoride on C-reactive protein, adenosine deaminase, and ceruloplasmin in rabbit sera

被引：0

作者：

Cenesiz, Sena ^{[1
]}

Yarim, Gul Fatma ^{[1
]}

Nisbet, Cevat ^{[1
]}

Ciftci, Gulay ^{[1
]}

机构：

[1] Ondokuz Mayis Univ, Dept Biochem, Fac Vet Med, TR-55139 Samsun, Turkey

来源：

FLUORIDE | 2008年 / 41卷 / 01期

关键词：

adenosine deaminase; C-reactive protein; ceruloplasmin; fluoride in rabbits;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Twenty healthy 6-month-old male and female New Zealand rabbits with a mean body weight of 3.5 +/- 0.5 kg were fed a standard commercial rabbit diet and provided with water ad libitum containing 40 mg F/L for 70 days. Blood samples were obtained from each rabbit, and sera adenosine deaminase (ADA) activity and C-reactive protein (CRP) and ceruloplasmin (CP) levels were determined with the following results at the start, at day 35, and at day 70, respectively: ADA activity 9.56 +/- 0.66, 14.78 +/- 1.11, and 19.56 +/- 1.85 U/L; CRP level 18.1 +/- 2.6, 85.5 +/- 20.3, and 123 +/- 23.26 ng/mL; CP level 22.19 +/- 2.66,19.49 +/- 1.18, and 14.75 +/- 0.96 mg/dL. By days 35 and 70 significant increases in ADA activity and CRP levels had occurred, along with a significant decrease in the CP level. These results demonstrated that fluoride intoxication caused significant alterations in ADA, CRP, and CP in rabbit sera.

引用

页码：52 / 56

页数：5

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