Preliminary study of copper oxide nanoparticles acoustic and magnetic properties for medical imaging

被引:0
作者
Perlman, Or [1 ]
Weitz, Iris S. [2 ]
Azhari, Haim [1 ]
机构
[1] Technion Israel Inst Technol, Dept Biomed Engn, Technion City, IL-32000 Haifa, Israel
[2] ORT Braude Coll, Dept Biotechnol Engn, IL-21982 Karmiel, Israel
来源
MEDICAL IMAGING 2015: PHYSICS OF MEDICAL IMAGING | 2015年 / 9412卷
关键词
multimodal imaging; nanoparticles; contrast agent; copper oxide; magnetic resonance imaging; ultrasound; CANCER; NANOCRYSTALS;
D O I
10.1117/12.2081628
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
The implementation of multimodal imaging in medicine is highly beneficial as different physical properties may provide complementary information, augmented detection ability, and diagnosis verification. Nanoparticles have been recently used as contrast agents for various imaging modalities. Their significant advantage over conventional large-scale contrast agents is the ability of detection at early stages of the disease, being less prone to obstacles on their path to the target region, and possible conjunction to therapeutics. Copper ions play essential role in human health. They are used as a cofactor for multiple key enzymes involved in various fundamental biochemistry processes. Extremely small size copper oxide nanoparticles (CuO-NPs) are readily soluble in water with high colloidal stability yielding high bioavailability. The goal of this study was to examine the magnetic and acoustic characteristics of CuO-NPs in order to evaluate their potential to serve as contrast imaging agent for both MRI and ultrasound. CuO-NPs 7nm in diameter were synthesized by hot solution method. The particles were scanned using a 9.4T MRI and demonstrated a concentration dependent T1 relaxation time shortening phenomenon. In addition, it was revealed that CuO-NPs can be detected using the ultrasonic B-scan imaging. Finally, speed of sound based ultrasonic computed tomography was applied and showed that CuO-NPs can be clearly imaged. In conclusion, the preliminary results obtained, positively indicate that CuO-NPs may be imaged by both MRI and ultrasound. The results motivate additional in-vivo studies, in which the clinical utility of fused images derived from both modalities for diagnosis improvement will be studied.
引用
收藏
页数:6
相关论文
共 14 条
[1]   Reexamining the effects of particle size and surface chemistry on the magnetic properties of iron oxide nanocrystals: New insights into spin disorder and proton relaxivity [J].
Duan, Hongwei ;
Kuang, Min ;
Wang, Xiaoxia ;
Wang, Y. Andrew ;
Mao, Hui ;
Nie, Shuming .
JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (22) :8127-8131
[2]   Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives [J].
Hahn, Megan A. ;
Singh, Amit K. ;
Sharma, Parvesh ;
Brown, Scott C. ;
Moudgil, Brij M. .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2011, 399 (01) :3-27
[3]  
Kak AvinashC., 2001, CLASSICS APPL MATH, V33
[4]   Nanoparticles for multimodal in vivo imaging in nanomedicine [J].
Key, Jaehong ;
Leary, James F. .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 :711-726
[5]   Tumor-Homing Glycol Chitosan-Based Optical/PET Dual Imaging Nanoprobe for Cancer Diagnosis [J].
Lee, Sangmin ;
Kang, Sun-Woong ;
Ryu, Ju Hee ;
Na, Jin Hee ;
Lee, Dong-Eun ;
Han, Seung Jin ;
Kang, Choong Mo ;
Choe, Yearn Seong ;
Lee, Kyo Chul ;
Leary, James F. ;
Choi, Kuiwon ;
Lee, Kyung-Han ;
Kim, Kwangmeyung .
BIOCONJUGATE CHEMISTRY, 2014, 25 (03) :601-610
[6]   Tumor Targeting Chitosan Nanoparticles for Dual-Modality Optical/MR Cancer Imaging [J].
Nam, Taehwan ;
Park, Sangjin ;
Lee, Seung-Young ;
Park, Kyeongsoon ;
Choi, Kuiwon ;
Song, In Chan ;
Han, Moon Hee ;
Leary, James J. ;
Yuk, Simseok Andrew ;
Kwon, Ick Chan ;
Kim, Kwangmeyung ;
Jeong, Seo Young .
BIOCONJUGATE CHEMISTRY, 2010, 21 (04) :578-582
[7]   Nanotechnology applications in cancer [J].
Nie, Shuming ;
Xing, Yun ;
Kim, Gloria J. ;
Simons, Jonathan W. .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2007, 9 :257-288
[8]   CONTRAST AGENTS IN DIAGNOSTIC ULTRASOUND [J].
OPHIR, J ;
PARKER, KJ .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1989, 15 (04) :319-333
[9]   Synthesis of NanoQ, a Copper-Based Contrast Agent for High-Resolution Magnetic Resonance Imaging Characterization of Human Thrombus [J].
Pan, Dipanjan ;
Caruthers, Shelton D. ;
Senpan, Angana ;
Yalaz, Ceren ;
Stacy, Allen J. ;
Hu, Grace ;
Marsh, Jon N. ;
Gaffney, Patrick J. ;
Wickline, Samuel A. ;
Lanza, Gregory M. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (24) :9168-9171
[10]   INVESTIGATION OF ACOUSTIC CHANGES RESULTING FROM CONTRAST ENHANCEMENT IN THROUGH-TRANSMISSION ULTRASONIC IMAGING [J].
Rothstein, Tamara ;
Gaitini, Diana ;
Gallimidi, Zahava ;
Azhari, Haim .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2010, 36 (09) :1395-1404