Liquid biopsy for brain tumors

被引：121

作者：

Shankar, Ganesh M. ^{[1
]}

Balaj, Leonora ^{[1
]}

Stott, Shannon L. ^{[2
]}

Nahed, Brian ^{[2
]}

Carter, Bob S. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Med, Canc Ctr, Boston, MA 02114 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2017年 / 17卷 / 10期

关键词：

Liquid biopsy; circulating tumor cells; exosome; cell free tumor DNA; brain tumors; CEREBROSPINAL-FLUID; CELL; DNA; GROWTH; RNA;

D O I：

10.1080/14737159.2017.1374854

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Introduction: Minimally invasive methods will augment the clinical approach for establishing the diagnosis or monitoring treatment response of central nervous system tumors. Liquid biopsy by blood or cerebrospinal fluid sampling holds promise in this regard. Areas covered: In this literature review, the authors highlight recent studies describing the analysis of circulating tumor cells, cell free nucleic acids, and extracellular vesicles as strategies to accomplish liquid biopsy in glioblastoma and metastatic tumors. The authors then discuss the continued efforts to improve signal detection, standardize the liquid biopsy handling and preparation, develop platforms for clinical application, and establish a role for liquid biopsies in personalized medicine. Expert commentary: As the technologies used to analyze these biomarkers continue to evolve, we propose that there is a future potential to precisely diagnose and monitor treatment response with liquid biopsies.

引用

页码：943 / 947

页数：5

共 35 条

[1]

Akers JC., 2015, Oncotarget, V6, P20829

[2] Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid [J].

Akers, Johnny C. ;

Ramakrishnan, Valya ;

Yang, Isaac ;

Hua, Wei ;

Mao, Ying ;

Carter, Bob S. ;

Chen, Clark C. .

CANCER BIOMARKERS, 2016, 17 (02) :125-132

[3] Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF) [J].

Akers, Johnny C. ;

Ramakrishnan, Valya ;

Nolan, John P. ;

Duggan, Erika ;

Fu, Chia-Chun ;

Hochberg, Fred H. ;

Chen, Clark C. ;

Carter, Bob S. .

PLOS ONE, 2016, 11 (02)

[4] miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development [J].

Akers, Johnny C. ;

Ramakrishnan, Valya ;

Kim, Ryan ;

Skog, Johan ;

Nakano, Ichiro ;

Pingle, Sandeep ;

Kalinina, Juliya ;

Hua, Wei ;

Kesari, Santosh ;

Mao, Ying ;

Breakefield, Xandra O. ;

Hochberg, Fred H. ;

Van Meir, Erwin G. ;

Carter, Bob S. ;

Chen, Clark C. .

PLOS ONE, 2013, 8 (10)

[5] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[6] Microfluidic isolation and transcriptome analysis of serum microvesicles [J].

Chen, Chihchen ;

Skog, Johan ;

Hsu, Chia-Hsien ;

Lessard, Ryan T. ;

Balaj, Leonora ;

Wurdinger, Thomas ;

Carter, Bob S. ;

Breakefield, Xandra O. ;

Toner, Mehmet ;

Irimia, Daniel .

LAB ON A CHIP, 2010, 10 (04) :505-511

[7] Alu methylation serves as a biomarker for non-invasive diagnosis of glioma [J].

Chen, Jian ;

Huan, Wei ;

Zuo, Hao ;

Zhao, Longxiang ;

Huang, Chuanjun ;

Liu, Xiaojiang ;

Hou, Shiqiang ;

Qi, Jing ;

Shi, Wei .

ONCOTARGET, 2016, 7 (18) :26099-26106

[8] BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles [J].

Chen, Walter W. ;

Balaj, Leonora ;

Liau, Linda M. ;

Samuels, Michael L. ;

Kotsopoulos, Steve K. ;

Maguire, Casey A. ;

LoGuidice, Lori ;

Soto, Horacio ;

Garrett, Matthew ;

Zhu, Lin Dan ;

Sivaraman, Sarada ;

Chen, Clark ;

Wong, Eric T. ;

Carter, Bob S. ;

Hochberg, Fred H. ;

Breakefield, Xandra O. ;

Skog, Johan .

MOLECULAR THERAPY-NUCLEIC ACIDS, 2013, 2 :e109

[9] Circulating mutant DNA to assess tumor dynamics [J].

Diehl, Frank ;

Schmidt, Kerstin ;

Choti, Michael A. ;

Romans, Katharine ;

Goodman, Steven ;

Li, Meng ;

Thornton, Katherine ;

Agrawal, Nishant ;

Sokoll, Lori ;

Szabo, Steve A. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Diaz, Luis A., Jr. .

NATURE MEDICINE, 2008, 14 (09) :985-990

[10] Circulating tumor cell technologies [J].

Ferreira, Meghaan M. ;

Romani, Vishnu C. ;

Jeffrey, Stefanie S. .

MOLECULAR ONCOLOGY, 2016, 10 (03) :374-394

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