Thyroid hormone and phenotypes of cardioprotection

被引：73
作者：
Pantos, C
Malliopoulou, V
Varonos, DD
Cokkinos, DV
机构：
[1] Univ Athens, Dept Pharmacol, Athens 11527, Greece
[2] Onassis Cardiac Surg Ctr, Cardiol Dept 1, Athens 17674, Greece
来源：
BASIC RESEARCH IN CARDIOLOGY | 2004年 / 99卷 / 02期
关键词：
thyroid hormone; cardiovascular system; phenotype of cardioprotection; intracellular kinases; ischaemia and reperfusion;
D O I：
10.1007/s00395-003-0449-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thyroid hormone has multiple effects on the cardiovascular system with important physiological consequences. Several genes that encode important regulatory and structural proteins in the heart have been shown to be thyroid hormone responsive. More notably, certain effects of thyroid hormone have been exploited therapeutically. Thyroid hormone is currently being evaluated as an inotrope and vasodilator in various clinical settings. Furthermore, new information has been recently accumulated on the role of thyroid hormone in the response of the heart to ischaemic stress. In fact, hyperthyroid and hypothyroid hearts display a phenotype of cardioprotection against ischaemia-reperfusion. Based on this evidence, the various actions of thyroid hormone on the cardiovascular system are highlighted in this review. Thyroid hormone, although limited by its adverse effects, might prove a suitable treatment for cardiovascular illnesses. Various thyroid hormone analogues are currently under development.
引用
收藏
页码：101 / 120
页数：20
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