Synthesis of the cyclic heptapeptide core of callipeltin A

被引：8

作者：

Horn, Alexander ^{[1
]}

Kazmaier, Uli ^{[1
]}

机构：

[1] Saarland Univ, Inst Organ Chem, POB 151150, D-66041 Saarbrucken, Germany

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 19期

关键词：

PROTECTED (2R,3R,4S)-4,7-DIAMINO-2,3-DIHYDROXYHEPTANOIC ACID; PHASE TOTAL-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; MARINE SPONGE; BETA-METHOXYTYROSINE; AMINO-ACID; EFFICIENT MACROLACTONIZATION; DIASTEREOSELECTIVE SYNTHESIS; ABSOLUTE STEREOCHEMISTRY; ASYMMETRIC-SYNTHESIS;

D O I：

10.1039/d2qo01120d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Macrolactonisation of a novel heptapeptide precursor with PyAOP proved to be an excellent method for preparation of the cyclic depsipeptide core of callipeltin A. The individual building blocks were obtained in high yield and selectivity and successive coupling allowed for the straightforward preparation of the linear heptapeptide from tyrosine 6 in 27% over 12 steps.

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收藏

页码：5213 / 5218

页数：6

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