The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis

被引：34
作者：
Adhya, Zoe [1 ]
Borozdenkova, Svetlana [1 ]
Karim, Mohammed Yousuf [1 ]
机构：
[1] Guys & St Thomas NHS Fdn Trust, St Thomas Hosp, Dept Immunol, London, England
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2011年 / 26卷 / 10期
关键词：
biomarker; cytokines; nephritis; systemic lupus erythematosus; TUMOR-NECROSIS-FACTOR; GELATINASE-ASSOCIATED LIPOCALIN; DISEASE-ACTIVITY; URINARY SEDIMENT; GENE-EXPRESSION; RENAL EXPRESSION; MESSENGER-RNA; GROWTH-FACTOR; SERUM-LEVELS; FACTOR-ALPHA;
D O I：
10.1093/ndt/gfq860
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Cytokines play an important role in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis. This is currently a very active area of research. Of particular interest is the use of cytokines as biomarkers of disease activity in SLE and lupus nephritis. Can cytokine measurements assist in early detection of renal flare in known lupus nephritis? Can such measurements be used to distinguish between flare and chronic damage? Or help to confirm renal remission? Could they be used to help assess the required duration of immunosuppression and reduce the need for invasive renal biopsy? This review discusses limitations of current laboratory methods in monitoring SLE, how measurements of cytokines may contribute in relation to following disease activity and summarizes what is known about cytokines as biomarkers in SLE and lupus nephritis.
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收藏
页码：3273 / 3280
页数：8
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