Difficult Therapeutic Decisions in Gorham-Stout Disease-Case Report and Review of the Literature

被引：4
|
作者：
Wojciechowska-Durczynska, Katarzyna [1 ,2 ]
Zygmunt, Arkadiusz [1 ,2 ]
Mikulak, Marta [2 ]
Ludwisiak, Marta [2 ]
Lewinski, Andrzej [1 ,2 ]
机构：
[1] Med Univ Lodz, Dept Endocrinol & Metab Dis, PL-93338 Lodz, Poland
[2] Polish Mothers Mem Hosp, Res Inst, Dept Endocrinol & Metab Dis, PL-93338 Lodz, Poland
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2022年 / 19卷 / 18期
关键词：
osteolysis; lymphogenesis; zoledronic acid; sirolimus; therapy; OSTEOCLAST FORMATION; BONE-RESORPTION; MECHANISMS; SIROLIMUS; CELLS;
D O I：
10.3390/ijerph191811692
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a 42-year-old female with GSD manifested in multifocal osteolysis and chronic chylothorax and ascites. The combined treatment with sirolimus and zoledronic acid due to its synergism of action was introduced. To our knowledge, this is the first Polish case report of adult patients with Gorham-Stout disease.
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页数：8
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