Molecular Regulation of Notch Signaling by Gremlin

被引：10

作者：

Marquez-Exposito, Laura ^{[1
,2
]}

Cantero-Navarro, Elena ^{[1
,2
]}

Rodrigues-Diez, Raul R. ^{[1
,2
]}

Orejudo, Macarena ^{[1
,2
]}

Tejera-Munoz, Antonio ^{[1
,2
]}

Tejedor, Lucia ^{[1
,2
]}

Rayego-Mateos, Sandra ^{[1
,3
]}

Randez-Carbayo, Javier ^{[1
,2
]}

Santos-Sanchez, Laura ^{[1
,2
]}

Mezzano, Sergio ^{[4
]}

Lavoz, Carolina ^{[4
]}

Ruiz-Ortega, Marta ^{[1
,2
]}

机构：

[1] Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Cellular & Mol Biol Renal & Vasc Pathol, Madrid, Spain

[2] Red Invest Renal REDINREN, Madrid, Spain

[3] Inst Recerca Biomed Lleida IRBLleida, Vasc & Renal Translat Res Grp, Lleida, Spain

[4] Univ Austral Chile, Sch Med, Div Nephrol, Valdivia, Chile

来源：

NOTCH SIGNALING IN EMBRYOLOGY AND CANCER: MOLECULAR BIOLOGY OF NOTCH SIGNALING, 2ND EDITION | 2020年 / 1227卷

关键词：

Gremlin; Notch; TGF-beta; BMP; VEGFR2; Renal damage; Fibrosis; Inflammation; BONE MORPHOGENETIC PROTEIN; NF-KAPPA-B; TGF-BETA; ANTAGONIST; EXPRESSION; PATHWAY; GROWTH; FIBROSIS; GENE; INFLAMMATION;

D O I：

10.1007/978-3-030-36422-9_6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gremlin is a member of the TGF-beta superfamily that can act as a BMP antagonist, and recently, has been described as a ligand of the vascular endothelial growth factor receptor 2 (VEGFR2). Gremlin shares properties with the Notch signaling pathway. Both participate in embryonic development and are reactivated in pathological conditions. Gremlin is emerging as a potential therapeutic target and biomarker of renal diseases. Here we review the role of the Gremlin-VEGFR2 axis in renal damage and downstream signaling mechanisms, such as Notch pathway.

引用

页码：81 / 94

页数：14

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