Challenging treatment for refractory acquired haemophilia A complicated with severe severe acute respiratory coronavirus 2 infection

被引：0
作者：
Lado Cives, Tamara [1 ]
Fernandez Docampo, Marta [1 ]
Fernandez Fernandez, Maria Teresa [1 ]
Martinez Senaris, Diana [1 ]
Hevilla Carmona, Alejandro [1 ]
Perez-Rodriguez, Almudena [1 ]
del Castillo Solano, Maria del carmen Gomez [1 ]
Lopez Fernandez, Maria Fernanda [1 ]
机构：
[1] Complexo Hosp Univ A Coruna, Hosp Materno Infantil, La Coruna, Spain
来源：
BLOOD COAGULATION & FIBRINOLYSIS | 2022年 / 33卷 / 06期
关键词：
acquired haemophilia; coronavirus disease 2019; low-molecular-weight heparin; mofetil mycophenolate; recombinant porcine factor VIII; severe acute respiratory coronavirus 2; PORCINE FACTOR-VIII; CLINICAL CHARACTERISTICS; DISEASE; 2019; RECOMBINANT; SEQUENCE; HEMOSTASIS; MANAGEMENT; SAFETY; OBI-1;
D O I：
10.1097/MBC.0000000000001149
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immunosuppressive treatment and bypassing agents are used to treat acquired haemophilia A (AHA). On the other hand, COVID-19 infection induces a hypercoagulable state. Managing bleeding, risk of thrombosis, bypassing agents, active infection and immunosuppressive treatment can be challenging. A 72-year-old man was diagnosed with acquired hemophilia A. He received steroids, rituximab and recombinant activated factor VII (rFVIIa). He developed severe SARS-CoV-2 infection. Due to thrombotic risk, he received low-molecular-weight heparin (LMWH) and developed an iliopsoas hematoma. Because of the risk of thrombosis, treatment with recombinant porcine FVIII (rpFVIII) was requested. Tocilizumab was administered for treatment of SARS-CoV-2 infection and unexpected improvement of FVIII levels was noted. Concluding, rpFVIII treatment was well tolerated and effective, easy to monitor and to administer. Tocilizumab may play a role as immunosuppressive treatment for AHA. The role of LMWH remains to be established in patients with coagulopathies.
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收藏
页码：342 / 347
页数：6
相关论文
共 34 条
  • [1] Mycophenolate mofetil and its mechanisms of action
    Allison, AC
    Eugui, EM
    [J]. IMMUNOPHARMACOLOGY, 2000, 47 (2-3): : 85 - 118
  • [2] [Anonymous], PROTOCOLO HOSPITALAR
  • [3] Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry
    Baudo, Francesco
    Collins, Peter
    Huth-Kuehne, Angela
    Levesque, Herve
    Marco, Pascual
    Nemes, Laszlo
    Pellegrini, Fabio
    Tengborn, Lilian
    Knoebl, Paul
    Aspoeck, G.
    Heistinger, M.
    Knobl, P.
    Makipernaa, A.
    André, H.
    Aouba, A.
    Bellucci, S.
    Beurrier, P.
    Borg, J. Y.
    Darnige, L.
    Devignes, J.
    d'Oiron, R.
    Gautier, P.
    Gay, V.
    Girault, S.
    Gruel, Y.
    Guerin, V.
    Hézard, N.
    Khellaf, M.
    Koenig, M.
    Lévesque, H.
    Lifermann, F.
    Marlu, R.
    Ninet, J.
    Peynet, J.
    Quemeneur, T.
    Rothschild, C.
    Schleinitz, N.
    Sigaud, M.
    Trouillier, S.
    Voisin, S.
    Giebl, A.
    Holstein, K.
    Huth-Kuhne, A.
    Loreth, R. M.
    Steigerwald, U.
    Tiede, A.
    Theodossiades, G.
    Nemes, L.
    Radvanyi, G.
    Schlammadinger, A.
    [J]. BLOOD, 2012, 120 (01) : 39 - 46
  • [4] Remdesivir for the Treatment of Covid-19-Final Report
    Beigel, John H.
    Tomashek, Kay M.
    Dodd, Lori E.
    Mehta, Aneesh K.
    Zingman, Barry S.
    Kalil, Andre C.
    Hohmann, Elizabeth
    Chu, Helen Y.
    Luetkemeyer, Annie
    Kline, Susan
    de Castilla, Diego Lopez
    Finberg, Robert W.
    Dierberg, Kerry
    Tapson, Victor
    Hsieh, Lanny
    Patterson, Thomas F.
    Paredes, Roger
    Sweeney, Daniel A.
    Short, William R.
    Touloumi, Giota
    Lye, David Chien
    Ohmagari, Norio
    Oh, Myoung-don
    Ruiz-Palacios, Guillermo M.
    Benfield, Thomas
    Faetkenheuer, Gerd
    Kortepeter, Mark G.
    Atmar, Robert L.
    Creech, C. Buddy
    Lundgren, Jens
    Babiker, Abdel G.
    Pett, Sarah
    Neaton, James D.
    Burgess, Timothy H.
    Bonnett, Tyler
    Green, Michelle
    Makowski, Mat
    Osinusi, Anu
    Nayak, Seema
    Lane, H. Clifford
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) : 1813 - 1826
  • [5] Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study
    Carsana, Luca
    Sonzogni, Aurelio
    Nasr, Ahmed
    Rossi, Roberta Simona
    Pellegrinelli, Alessandro
    Zerbi, Pietro
    Rech, Roberto
    Colombo, Riccardo
    Antinori, Spinello
    Corbellino, Mario
    Galli, Massimo
    Catena, Emanuele
    Tosoni, Antonella
    Gianatti, Andrea
    Nebuloni, Manuela
    [J]. LANCET INFECTIOUS DISEASES, 2020, 20 (10) : 1135 - 1140
  • [6] Immunosuppression for acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)
    Collins, Peter
    Baudo, Francesco
    Knoebl, Paul
    Levesque, Herve
    Nemes, Laszlo
    Pellegrini, Fabio
    Marco, Pascual
    Tengborn, Lilian
    Huth-Kuehne, Angela
    Aspoeck, Gerold
    Heistinger, Max
    Knobl, Paul
    Makipernaa, Anne
    Andre, Helene
    Aouba, A.
    Bellucci, Sylvia
    Beurrier, Philippe
    Borg, Jeanne Yvonne
    Darnige, Luc
    Devignes, Jean
    d'Oiron, Roseline
    Gautier, Philippe
    Gay, Valerie
    Girault, Stephane
    Gruel, Yves
    Guerin, Viviane
    Hezard, Nathalie
    Khellaf, Mehdi
    Koenig, Martial
    Lifermann, Francois
    Marlu, Raphael
    Ninet, J.
    Peynet, Jocelyne
    Quemeneur, Thomas
    Rothschild, Chantal
    Schleinitz, Nicolas
    Sigaud, Marianne
    Trouillier, Sebastien
    Voisin, Sophie
    Giebl, Andreas
    Holstein, Katharina
    Huth-Kuhne, Angela
    Loreth, Ralph M.
    Steigerwald, Udo
    Tiede, Andreas
    Theodossiades, George
    Radvanyi, Gaspar
    Schlammadinger, Agota
    Barillari, Giovanni
    Pasca, Samantha
    [J]. BLOOD, 2012, 120 (01) : 47 - 55
  • [7] Confronting COVID-19: Issues in Hemophilia and Congenital Bleeding Disorders
    Coppola, Antonio
    Tagliaferri, Annarita
    Rivolta, Gianna Franca
    Quintavalle, Gabriele
    Franchini, Massimo
    [J]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2020, 46 (07) : 819 - 822
  • [8] Acquired hemophilia A: a review of recent data and new therapeutic options
    Franchini, Massimo
    Vaglio, Stefania
    Marano, Giuseppe
    Mengoli, Carlo
    Gentili, Sara
    Pupella, Simonetta
    Liumbruno, Giancarlo Maria
    [J]. HEMATOLOGY, 2017, 22 (09) : 514 - 520
  • [9] Compassionate Use of Remdesivir for Patients with Severe Covid-19
    Grein, J.
    Ohmagari, N.
    Shin, D.
    Diaz, G.
    Asperges, E.
    Castagna, A.
    Feldt, T.
    Green, G.
    Green, M. L.
    Lescure, F-X
    Nicastri, E.
    Oda, R.
    Yo, K.
    Quiros-Roldan, E.
    Studemeister, A.
    Redinski, J.
    Ahmed, S.
    Bernett, J.
    Chelliah, D.
    Chen, D.
    Chihara, S.
    Cohen, S. H.
    Cunningham, J.
    Monforte, A. DArminio
    Ismail, S.
    Kato, H.
    Lapadula, G.
    L'Her, E.
    Maeno, T.
    Majumder, S.
    Massari, M.
    Mora-Rillo, M.
    Mutoh, Y.
    Nguyen, D.
    Verweij, E.
    Zoufaly, A.
    Osinusi, A. O.
    DeZure, A.
    Zhao, Y.
    Zhong, L.
    Chokkalingam, A.
    Elboudwarej, E.
    Telep, L.
    Timbs, L.
    Henne, I
    Sellers, S.
    Cao, H.
    Tan, S. K.
    Winterbourne, L.
    Desai, P.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (24) : 2327 - 2336
  • [10] Clinical Characteristics of Coronavirus Disease 2019 in China
    Guan, W.
    Ni, Z.
    Hu, Yu
    Liang, W.
    Ou, C.
    He, J.
    Liu, L.
    Shan, H.
    Lei, C.
    Hui, D. S. C.
    Du, B.
    Li, L.
    Zeng, G.
    Yuen, K. -Y.
    Chen, R.
    Tang, C.
    Wang, T.
    Chen, P.
    Xiang, J.
    Li, S.
    Wang, Jin-lin
    Liang, Z.
    Peng, Y.
    Wei, L.
    Liu, Y.
    Hu, Ya-hua
    Peng, P.
    Wang, Jian-ming
    Liu, J.
    Chen, Z.
    Li, G.
    Zheng, Z.
    Qiu, S.
    Luo, J.
    Ye, C.
    Zhu, S.
    Zhong, N.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (18) : 1708 - 1720
1234